The effects of dietary polyphenols on reproductive health and early development

Human Reproduction UpdateVolume 21, Issue 2, 2015, Article number dmu058, Pages 228-248

(Article)

• Ly, C.^abEmail Author,
 
• Yockell-Lelièvre, J.^b,
 
• Ferraro, Z.M.^c,
 
• Arnason, J.T.^d,
 
• Ferrier, J.^abde,
 
• Gruslin, A.^abc
 
• View Correspondence (jump link)

• ^aDepartment of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada
• ^bChronic Disease Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada
• ^cDivision of Maternal-Fetal Medicine, The Ottawa Hospital, Ottawa, ON, Canada

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Abstract View references (274)

Background: Emerging evidence from clinical and epidemiological studies suggests that dietary polyphenols play an important role in the prevention of chronic diseases, including cancer, cardiovascular disease, diabetes and neurodegenerative disorders. Although these beneficial health claims are supported by experimental data for many subpopulation groups, some studies purport that excessive polyphenol consumption may have negative health effects in other subpopulations. The ever-growing interest and public awareness surrounding the potential benefits of natural health products and polyphenols, in addition to their widespread availability and accessibility through nutritional supplements and fortified foods, has led to increased consumption throughout gestation. Therefore, understanding the implications of polyphenol intake on obstetrical health outcomes is of utmost importance with respect to safe consumption during pregnancy. Methods: Using relevant keywords, a literature search was performed to gather information regarding polyphenol pharmacology and the molecular mechanisms by which polyphenols exert their biological effects. The primary focus of this paper is to understand the relevance of these findings in the context of reproductive physiology and medicine. Results: Evidence from both in vitro experiments and in vivo studies using animals and humans demonstrates that polyphenols regulate key targets related to oxidative stress, inflammation and advanced glycation end products. Although the majority of these studies havebeen conducted in the context of chronic diseases, such as cancer and diabetes, several of the key targets influenced by polyphenols are also related to a variety of obstetrical complications, including pre-eclampsia, intrauterine growth restriction and pretermbirth. Polyphenols have also been shown to influence fertility and sexual development, fetal health and the bioavailability of nutrients. Conclusions: Further research leading to a thorough understanding of the physiological roles and potential clinical value that polyphenol consumption may play in pregnancy is urgently needed to help inform patient safety. © The Author 2014. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved.

Author keywords

• Beneficial and adverse effects
 
• Molecular targets
 
• Polyphenols
 
• Pregnancy
 
• Reproduction

Indexed keywords

EMTREE drug terms:	apigenincaffeic acidcatechinchlorogenic acidchrysincurcumincyanidin 3 glucosideepicatechingallic acidgenisteinkaempferolluteolinmyricetinnaringeninpara coumaric acidpolyphenol derivativequercetinresveratrolrutosidesecoisolariciresinolsesaminsilibininxanthohumolpolyphenol
EMTREE medical terms:	Articlediet supplementationdrug absorptiondrug bioavailabilitydrug eliminationdrug metabolismfetal well beingfood compositionfood safetyhumanmaternal carematernal nutritionmaternal welfaremolecularly targeted therapynonhumanoxidative stressphysical chemistrypregnancy outcomeprenatal developmentpriority journalreproductive healthsystematic reviewtranslational researchanimalchemistryfemaleinflammationmetabolismmouseoxidative stresspreeclampsiapregnancyprematurity
MeSH:	AnimalsFemaleHumansInflammationMiceOxidative StressPolyphenolsPre-EclampsiaPregnancyPremature BirthReproductive Health

Chemicals and CAS Registry Numbers:

apigenin, 520-36-5; caffeic acid, 27323-69-9, 331-39-5; catechin, 13392-26-2, 154-23-4; chlorogenic acid, 327-97-9; chrysin, 12624-02-1, 480-40-0; curcumin, 458-37-7; cyanidin 3 glucoside, 7084-24-4; epicatechin, 490-46-0; gallic acid, 149-91-7; genistein, 446-72-0; kaempferol, 520-18-3; luteolin, 491-70-3; myricetin, 529-44-2; naringenin, 480-41-1, 67604-48-2; para coumaric acid, 7400-08-0; quercetin, 117-39-5; resveratrol, 501-36-0; rutoside, 153-18-4, 22519-99-9; secoisolariciresinol, 145265-02-7, 29388-59-8, 75365-01-4; sesamin, 607-80-7, 7076-24-6; silibinin, 22888-70-6; xanthohumol, 6754-58-1; polyphenol, 37331-26-3;

Polyphenols

• ISSN: 13554786
• CODEN: HRUPF
• Source Type: Journal
• Original language: English

• DOI: 10.1093/humupd/dmu058
• PubMed ID: 25376587
• Document Type: Article
• Publisher: Oxford University Press

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  Ly, C.; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada
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