Novel triterpenoids and glycosides from durian exert pronounced anti-inflammatory activities.

Food Chem. 2018 Feb 15;241:215-221. doi: 10.1016/j.foodchem.2017.08.097. Epub 2017 Sep 1. Feng J1, Yi X1, Huang W1, Wang Y2, He X3. Author information 1 School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China; Guangdong Engineering Research Center for Lead Compounds & Drug Discovery, Guangzhou 510006, China. 2 School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China; Guangdong Engineering Research Center for Lead Compounds & Drug Discovery, Guangzhou 510006, China. Electronic address: wangyih88@163.com. 3 School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China; Guangdong Engineering Research Center for Lead Compounds & Drug Discovery, Guangzhou 510006, China. Electronic address: hexj@gdpu.edu.cn. Abstract Durian, known for its abundant nutrition, is a delicious fruit from Southeast Asia with increasing popularity worldwide. In this study, a series of chromatographic methods and bioactivity assays were applied to identify major compounds from durian shells. Two new triterpenoids, two new phenolics, and seven new glycoside esters, as well as sixteen known compounds, were isolated and identified. Anti-inflammatory activities were assayed and evaluated for the isolated compounds. Most of the isolated compounds exhibited pronounced inhibitory activities on lipopolysaccharides-induced NO production in RAW 264.7 cells. The results indicated that durian shells could serve as anti-inflammatory agents for functional food or medicinal use. This study additionally provided motivation for the ecological protection of durian shells. Copyright © 2017 Elsevier Ltd. All rights reserved. KEYWORDS: Anti-inflammatory activity; Durian; Durio zibethinus; Glycosides; Triterpenoids PMID: 28958521 DOI: 10.1016/j.foodchem.2017.08.097