Two new lignans from the resin of Bursera microphylla A. gray and their cytotoxic activity

Nat Prod Res. 2017 Sep 18:1-6. doi: 10.1080/14786419.2017.1375922. [Epub ahead of print] . Gigliarelli G1, Zadra C1, Cossignani L1, Robles Zepeda RE2, Rascón-Valenzuela LA2, Velázquez-Contreras CA2, Marcotullio MC1. Author information 1 a Department of Pharmaceutical Sciences , University of Perugia , Perugia , Italy. 2 b Departamento de Ciencias Químico Biológicas, División de Ciencias Biológicas y de la Salud , Universidad de Sonora , Hermosillo , Mexico. Abstract Two new lignans, namely 7-O-podophyllotoxinyl butyrate (1) and dihydroclusin 9-acetate (2), were isolated from the dichloromethane fraction of a methanol extract of Bursera microphylla (Burseraceae), along with eight known lignans (3-10). Their structures were determined by means of comprehensive spectroscopic analysis. Lignans 2-6 were tested for their anti-proliferative activity on the cancer cell lines LS180, A549 and HeLa, and on a non-cancer cell line, ARPE-19. Only compounds 4 and 5 showed an interesting activity on HeLa cells. KEYWORDS: 7-O-podophyllotoxinyl butyrate; Bursera microphylla; Burseraceae; anti-proliferative activity; dihydroclusin 9-acetate; lignans PMID: 28920481 DOI: 10.1080/14786419.2017.1375922