[Effectiveness of preventive treatment by Influenzinum in the winter period against the onset of influenza-like illnesses].

Therapie. 2017 Sep;72(4):465-474. doi: 10.1016/j.therap.2016.12.011. Epub 2017 Feb 17. [Article in French] Marinone C1, Bastard M1, Bonnet PA1, Gentile G1, Casanova L2. Author information 1 Département de médecine générale, Aix-Marseille université, 27, boulevard Jean-Moulin, 13385 Marseille cedex 05, France. 2 Département de médecine générale, Aix-Marseille université, 27, boulevard Jean-Moulin, 13385 Marseille cedex 05, France. Electronic address: ludovic.casanova@inserm.fr. Abstract AIM: In vitro Influenzinum induce a cellular change. We present the results of the first study examining the effectiveness of Influenzinum against influenza-like illnesses. METHOD: Retrospective cohort study during winter 2014-2015. After influenza epidemic, a self-assessment questionnaire was offered to patients presenting for a consultation. The primary endpoint was the declaration of an influenza-like illness. The exposed patients (treated by Influenzinum) were matched to two non-exposed patients (untreated) with a propensity score. A conditional logistic model expressed influenza-like illness risk reduction provided by the Influenzinum. RESULTS: The cohort included 3514 patients recruited from 46 general practitioners. After matching, the treated group (n=2041) and the untreated group (n=482) did not differ on variables collected. Influenzinum preventive therapy does not significantly alter the likelihood of influenza-like illness (adjusted odds ratio=0,91 [0,62 to 1,35], p=0,64). CONCLUSION: Influenzinum preventive therapy did not appear effective in preventing influenza-like illness. Copyright © 2017 Société française de pharmacologie et de thérapeutique. Published by Elsevier Masson SAS. All rights reserved. KEYWORDS: Active immunization; Ambulatory care; Grippe humaine; Homeopathy; Homéopathie; Human influenza; Influenzinum; Médecine ambulatoire; Propensity score; Score de propension; Vaccination