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Friday 16 February 2018

Radix Stellariae extract prevents high-fat-diet-induced obesity in C57BL/6 mice by accelerating energy metabolism.

PeerJ. 2017 May 11;5:e3305. doi: 10.7717/peerj.3305. eCollection 2017. Li Y1, Liu X1, Fan Y1, Yang B1, Huang C1. Author information 1 School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, China. Abstract Stellaria dichotoma L. is widely distributed in Ningxia and surrounding areas in northwestern China. Its root, Radix Stellariae (RS), has been used in herbal formulae for treating asthenic-fever, infection, malaria, dyspepsia in children and several other symptoms. This study investigated whether the RS extract (RSE) alleviates metabolic disorders. The results indicated that RSE significantly inhibited body weight gain in high-fat (HF)-diet-fed C57BL/6 mice, reduced fasting glucose levels, and improved insulin tolerance. Moreover, RSE increased the body temperature of the mice and the expression of uncoupling proteins and peroxisome proliferator-activated receptors in the white adipose tissue. Thus, RSE alleviated metabolic disorders in HF-diet-fed C57BL/6 mice by potentially activating UCP and PPAR signaling. KEYWORDS: High-fat diet; Metabolic syndrome; PPARs; Radix stellariae; UCPs PMID: 28507819 PMCID: PMC5429735 DOI: 10.7717/peerj.3305 Free PMC Article - https://peerj.com/articles/3305/