ETHNOBOTANICAL USES, PHYTOCHEMISTRY AND PHARMACOLOGICAL ACTIVITIES OF PEPEROMIA PELLUCIDA (L.) KUNTH (PIPERACEAE)-A REVIEW

ISSN: 0975–1491 Raghavendra H. L., Prashith Kekuda T. R. Abstract Peperomia pellucida (L.) Kunth is a herb belonging to the family Piperaceae. In this review, an extensive literature survey was carried out to compile information available on medicinal uses, phytochemistry and pharmacological properties of P. pellucida. The plant is used as food, flavoring agent and as medicine. The plant is used as medicine for treating various ailments or disorders such as asthma, rheumatism, wound, fever, stomach problems, kidney infection, hemorrhoid pain, joint pain, hypertension, diarrhea, snake bite and measles. The plant contains phytochemical groups such as alkaloids, flavonoids, saponins, terpenoids, steroids and glycosides. Compounds such as dill apiole, phytol, stigmasterol, sitosterol, secolignans, tetrahydrofuran lignans, highly methoxylated dihydronaphthalenone, peperomins, sesamin and isoswertisin have been identified in the plant. Studies have shown that the plant exhibited several pharmacological activities such as antimicrobial, antioxidant, anti-angiogenic, anti-inflammatory, analgesic, antipyretic, neuropharmacological, antisickling, anticancer, enzyme inhibitory, antiulcer, hypotensive, immunostimulatory, fracture healing and antidiabetic activities which support the traditional use of the plant. Purified chemicals from the plant have also shown to exhibit certain pharmacological activities such as antiulcer, anticancer and antimicrobial activity. By this extensive literature review, it can be concluded that P. pellucida can be utilized as a promising candidate for developing newer drugs with potent pharmacological activities. Keywords Peperomia pellucida (L.) Kunth, Ethnomedicine, Traditional medicine, Phytochemical, Pharmacological activities | PDF | HTML | References Fabricant DS, Farnsworth NR. The value of plants used in traditional medicine for drug discovery. Environ Health Perspect 2001;109 Suppl 1:69-75. Pérez M, Boffill MA, Morón FJ, Sueiro ML, Marrero E, Betancourt E. Ethnopharmacological and preclinical study of diuretic activity in medicinal and food plants used by Cuban population. Emirates J Food Agric 2011;23:214-21. Ayyanar M. Traditional herbal medicines for primary healthcare among indigenous people in Tamil Nadu, India. J Homeopathy Ayurvedic Med 2013;2:140. Leonti M, Casu L. Traditional medicines and globalization: current and future perspectives in ethnopharmacology. Front Pharmacol 2013;4:92. Hong L, Guo Z, Huang K, Wei S, Liu B, Meng S, et al. Ethnobotanical study on medicinal plants used by Maonan people in China. J Ethnobiol Ethnomed 2015;11:32. Raghavendra HL, Kekuda PTR, Pushpavathi D, Shilpa M, Petkar T, Siddiqua A. Antimicrobial, radical scavenging, and insecticidal activity of leaf and flower extracts of Couroupita guianensis Aubl. Int J Green Pharm 2017;11:171-9. Fyson PF. The flora of the nilgiri and pulney hill-tops. Vol. I. Bishen Singh Mahendra Pal Singh, Dehra Dun and Periodical Experts, Delhi; 1974. p. 345. Bhat GK. Flora of South Kanara. Akriti Prints, Mangalore; 2014. p. 43. Vergara Rodriguez D, Mathieu G, Samain M, Armenta Montero S, Kromer T. Diversity, distribution, and conservation status of Peperomia (Piperaceae) in the state of veracruz, Mexico. Trop Conservation Sci 2017;10:1-28. Melo A, Guimaraes EF, Alves M. Synopsis of the genus Peperomia ruiz and pav. (Piperaceae) in roraima state, Brazil. Hoehnea 2016;43:119-34. Termote C, Van Damme P, Dhed'a Djailo B. Eating from the wild: Turumbu indigenous knowledge on noncultivated edible plants, Tshopo District, DR Congo. Ecol Food Nutr 2010;49:173-207. Coe FG, Anderson GJ. Ethnobotany of the sumu (Ulwa) of southeastern Nicaragua and comparisons with Miskitu plant lore. Econ Bot 1999;53:363-86. Whitney CW, Min VS, Giang LH, Can VV, Barber K, Lanh TT. Conservation and ethnobotanical knowledge of a Hmong community in long lan, Luang Prabang, Lao People’s Democratic Republic. Ethnobot Res Appl 2014;12:643-58. Hadi S, Bremner JB. Initial studies on alkaloids from Lombok medicinal plants. Molecules 2001;6:117-29. Das NJ, Saikia SP, Sarkar S, Devi K. Medicinal plants of North-Kamrup district of Assam used in primary healthcare system. Indian J Tradit Know 2006;5:489-93. Lans CA. Ethnomedicines used in trinidad and tobago for urinary problems and diabetes mellitus. J Ethnobiol Ethnomed 2006;2:45. Sonibare MA, Moody JO, Adesanya EO. Use of medicinal plants for the treatment of measles in Nigeria. J Ethnopharmacol 2009;122:268-72. Santos MRA, Lima MR, Oliveira CLLG. Medicinal plants used in Rondônia, Western Amazon, Brazil. Rev Bras Plant Med 2014;16 Suppl 1:707-20. Chukwuma EC, Soladoye MO, Feyisola RT. Traditional medicine and the future of medicinal plants in Nigeria. J Med Plants Studies 2015;3:23-9. Olowa L, Demayo CG. Ethnobotanical uses of medicinal plants among the muslim maranaos in Iligan city, Mindanao, Philippines. Adv Environ Biol 2015;9:204-15. Chithra M, Geetha SP. Plant based remedies for the treatment of rheumatism among six tribal communities in Malappuram district, Kerala. Int J Bot Studies 2016;1:47-54. Kalita GJ, Rout S, Mishra RK, Sarma P. Traditionally used medicinal plants of bajali subdivision, barpeta district, Assam. J Med Plants Studies 2015;3:8-17. Koch M, Kehop DA, Kinminja B, Sabak M, Wavimbukie G, Barrows KM, et al. An ethnobotanical survey of medicinal plants used in the East Sepik province of Papua New Guinea. J Ethnobiol Ethnomed 2015;11:79. Waty DR, Saputri FC, Munim A. Secondary metabolites screening and acute toxicity test of Peperomia pellucida (L.) Kunth methanolic extracts. Int J PharmTech Res 2017;10:31-8. Rahmatullah M, Mollik MAH, Paul AK, Jahan R, Khatun MA, Seraj S, et al. A comparative analysis of medicinal plants used to treat gastrointestinal disorders in two sub-districts of Greater Khulna division, Bangladesh. Adv Nat Appl Sci 2010;4:22-8. Mollik MAF, Hossan MS, Paul AK, Taufiq-Ur-Rahman M, Jahan R, Rahmatullah M. A comparative analysis of medicinal plants used by folk medicinal healers in three districts of Bangladesh and inquiry as to mode of selection of medicinal plants. Ethnobot Res Appl 2010;8:195-218. Buragohain J. Ethnomedicinal plants used by the ethnic communities of Tinsukia district of Assam, India. Recent Res Sci Technol 2011;3:31-42. Bharali P, Sharma CL, Singh B, Sharma M. Ethnobotanical studies of spice and condiment plants used by some communities of Assam. Int J Adv Sci Res 2017;3:1-11. Bordoloi R, Kashyap K, Das A. Ethno-medicinal study on the traditional herbal knowledge of the Tiwa tribe of Morigaon district of Assam, India. Asian J Sci Technol 2017;8:5484-9. Bose D. An ethno-medicobotanical investigation among Rava tribe of Jalpaiguri district. NBU J Plant Sci 2011;5:61-5. Rahmatullah M, Ayman U, Akter F, Sarker M, Sifa R, Sarker B, et al. Medicinal formulations of a Kanda tribal healer–A tribe on the verge of disappearance in Bangladesh. Afr J Tradit Complementary Altern Med 2013;10:213-22. Ruysschaert S, Van Andel T, Van de Putte K, Van Dammea P. Bathe the baby to make it strong and healthy: plant use and child care among saramaccan maroons in suriname. J Ethnopharmacol 2009;121:148-70. Vandebroek I, Balick MJ, Ososki A, Kronenberg F, Yukes J, Wade C, et al. The importance of botellas and other plant mixtures in dominican traditional medicine. J Ethnopharmacol 2010; 128:20-41. Uzodimma DE. Medico-ethnobotanical inventory of Ogii, Okigwe Imo state, South Eastern Nigeria-I. Global Adv Res J Med Plants 2013;2:30-44. Gogoi B, Zaman K. Phytochemical constituents of some medicinal plant species used in recipe during ‘Bohag Bihu’ in Assam. J Pharmacogn Phytochem 2013;2:30-40. Clement YN, Baksh Comeau YS, Seaforth CE. An ethnobotanical survey of medicinal plants in Trinidad. J Ethnobiol Ethnomed 2015;11:67. Das PR, Islam MT, Jahan R, Rahmatullah M. Ethnomedicinal plants used by the Nag clan of the Rai Ghatual tribe of Moulvibazar district, Bangladesh. Ancient Sci Life 2013;32:217–21. Bora R, Das AK. An inventory of ethnomedicinal plants among the rabha tribe residing nearby chandubi beel of kamrup district (Assam). Int J Innovative Res Sci Technol 2015;1:126-9. Ragasa CY, Dumato M, Rideout JA. Antifungal compounds from Peperomia pellucida. ACGC Chem Res Commun 1998;7:54-61. Sasidharan S, Chen Y, Saravanan D, Sundram KM, Latha YL. Extraction, isolation and characterization of bioactive compounds from plants' extracts. Afr J Tradit Complementary Altern Med 2011;8:1-10. Hartati S, Angelina M, Dewiyanti ID, Meiliawati L. Isolation and characterization compounds from hexane and ethyl acetate fractions of Peperomia pellucida L. J Trop Life Sci 2015;5:117-22. Papitha R, Ravi L, Selvaraj CI. Phytochemical studies and GC-MS analysis of Spermadictyon suaveolens Roxb. Int J Pharm Pharm Sci 2017;9:143-9. Kurniawan A, Saputri FC, Rissyelly, Ahmad I, Munim A. Isolation of angiotensin converting enzyme (ACE) inhibitory activity quercetin from Peperomia pellucida. Int J PharmTech Res 2016;9:115-21. Biswas SM. Optimized analytical techniques for extraction and separation of bioactive compounds from diverse plant types. Biochem Anal Biochem 2017;6:313. Ingle KP, Deshmukh AG, Padole DA, Dudhare MS, Moharil MP, Khelurkar VC. Phytochemicals: extraction methods, identification and detection of bioactive compounds from plant extracts. J Pharmacogn Phytochem 2017;6:32-6. Gini TG, Jothi JG. Preliminary phytochemical screening of whole plant extracts of Peperomia pellucida (Linn.) HBK (Piperaceae) and Marsilea quadrifolia Linn. (Marsileaceae). Int J Pharmacogn Phytochem Res 2013;5;200-14. Ojo OO, Ajayi SS, Owolabi LO. Phytochemical screening, anti-nutrient composition, proximate analyses and the antimicrobial activities of the aqueous and organic extracts of bark of Rauvolfia vomitoria and leaves of Peperomia pellucida. Int Res J Biochem Bioinformatics 2012;2:127-34. Majumder P, Kumar AKV. Establishment of quality parameters and pharmacognostic evaluation of leaves of Peperomia pellucida (L.) HBK. Int J Pharm Pharm Sci 2011;3:375-8. Omotayo FO, Borokini TI. Comparative phytochemical and ethnomedicinal survey of selected medicinal plants in Nigeria. Sci Res Essays 2012;7:989-99. Idris OO, Olatunji BP, Madufor P. In vitro antibacterial activity of the extracts of Peperomia pellucida (L). Br Microbiol Res J 2016;11:1-7. Abere TA, Okpalaonyagu SO. Pharmacognostic evaluation and antisickling activity of the leaves of Peperomia pellucida (L.) HBK (Piperaceae). Afr J Pharm Pharmacol 2015;9:561-6. Ibibia ET. Phytochemical and antimicrobial analyses of extracts of Peperomia pellucida (L). J Pharm Res 2012;5:2934-7. Majumder P. Phytochemical, pharmacognostical and physicochemical standardization of Peperomia pellucida (L.) HBK. stem. Int J Comprehensive Pharm 2011;8:1-4. Sheikh H, Sikder S, Paul SK, Hasan RAM, Rahaman MM, Kundu SP. Hypoglycemic, anti-inflammatory and analgesic activity of Peperomia pellucida (L.) HBK (Piperaceae). Int J Pharm Sci Res 2013;4:458-63. Egwuche RU, Odetola AA, Erukainure OL. Preliminary investigation into the chemical properties of Peperomia pellucida L. Res J Phytochem 2011;5:48-53. Raina MS, Hassan MD. Screening of phytochemical properties and antimicrobial activity of Malaysian medicinal plants against aquatic bacteria. Malays J Microbiol 2016;12:284-90. Da Silva MHL, Zoghbi MDGB, Andrade EHA, Maia JGS. The essential oils of Peperomia pellucida Kunth and P. circinnata Link var. circinnata. Flavour Fragrance J 1999;14:312–4. Wei LS, Wee W, Siong JYF, Syamsumir DF. Characterization of anticancer, antimicrobial, antioxidant properties and chemical compositions of Peperomia pellucida leaf extract. Acta Med Iranica 2011;49:670-4. Francois T, Michel JDP, Vyry WNA, Fabrice FB, Lambert SM, Henri AZP, et al. Composition and antifungal properties of essential oils from five plants growing in the mountainous area of the West Cameroon. J Essent Oil-Bear Plants 2013;16:679-88. Verma RS, Padalia RC, Goswami P, Chauhan A. Essential oil composition of Peperomia pellucida (L.) Kunth from India. J Essent Oil Res 2015;27:89-95. Narayanamoorthi V, Vasantha K, Rency RC, Maruthasalam A. GC MS determination of bioactive components of Peperomia pellucida (L.) Kunth. Biosci Discovery 2015;6:83-8. de Oliveira JCS, da Camara CAG, Neves RCS, Botelho PS. Chemical composition and acaricidal activity of essential oils from Peperomia pellucida Kunth against Tetranychus urticae. Rev Virtual Quim 2017;9:1-9. Okoh SO, Iweriebor BC, Okoh OO, Okoh AI. Bioactive constituents, radical scavenging, and antibacterial properties of the leaves and stem essential oils from Peperomia pellucida (L.) kunth. Pharmacogn Mag 2017;13 Suppl S3:392-400. Bayma JD, Arruda MS, Müller AH, Arruda AC, Canto WC. A dimeric ArC2 compound from Peperomia pellucida. Phytochemistry 2000;55:779-82. Xu S, Li N, Ning MM, Zhou CH, Yang QR, Wang MW. Bioactive compounds from Peperomia pellucida. J Nat Prod 2006;69:247-50. Khan A, Rahman M, Islam MS. Isolation and bioactivity of a xanthone glycoside from Peperomia pellucida. Life Sci Med Res 2010;LSMR-1:1-10. Leena PK, Annam C. Isolation and characterization of flavone glycoside vitexin from Peperomia pellucida Linn. J Drug Delivery Ther 2013;3:91-2. Susilawati Y, Nugraha R, Krishnan J, Muhtadi A, Sutardjo S, Supratman U. A new antidiabetic compound 8,9-dimethoxy ellagic acid from sasaladaan (Peperomia pellucida L. Kunth). Res J Pharm Biol Chem Sci 2017;8(1S):269-74. Ahmad I, Rissyelly, Kurniawan A, Munim A. Screening of extraction method for alkaloid enrichment of Peperomia pellucida (L.) Kunth. Asian J Pharm Clin Res 2017;10:214-9. Nwokocha CR, Owu DU, Kinlocke K, Murray J, Delgoda R, Thaxter K, et al. Possible mechanism of action of the hypotensive effect of Peperomia pellucida and interactions between human cytochrome P450 enzymes. Med Aromat Plants 2012;1:105. Fasola TR, Adeboye JO. Anti-hypertensive potentials of Peperomia pellucida (L.) HBK in anaesthetized normotensive rats. Adv Life Sci Technol 2015;29:1-4. Khan A, Rahman M, Islam MS. Neuropharmacological effects of Peperomia pellucida leaves in mice. DARU 2008;16:35-40. Lee SW, Sim KY, Wendy W, Zulhisyam AK. Peperomia pellucida leaf extract as immunostimulator in controlling motile aeromonad septicemia due to Aeromonas hydrophila in red hybrid tilapia, Oreochromis spp. farming. Vet World 2016;9:231-4. Camposano JE, Torre DGLT, Laxamana JG, Larcia LLH. Screening for the anti-angiogenic activity of selected Philippine medicinal plants using chorioallantoic membrane assay. Mahidol Univ J Pharm Sci 2016;43:173-82. Ngueguim FT, Khan MP, Donfack JH, Tewari D, Dimo T, Kamtchouing P, et al. Ethanol extract of Peperomia pellucida (Piperaceae) promotes fracture healing by an anabolic effect on osteoblasts. J Ethnopharmacol 2013;148:62-8. Florence NT, Huguette STS, Hubert DJ, Raceline GK, Desire DDP, Pierre K, et al. Aqueous extract of Peperomia pellucida (L.) HBK accelerates fracture healing in Wistar rats. BMC Complementary Altern Med 2017;17:188. Roslida AH, Aini NZ. Evaluation of gastroprotective effects of the ethanolic extract of Peperomia pellucida (L) Kunth. Pharmacologyonline 2009;2:676-86. Rojas Martinez R, Arrieta J, Cruz Antonio L, Arrieta Baez D, Velazquez Mendez AM, Sanchez Mendoza ME. Dillapiole, isolated from Peperomia pellucida, shows gastroprotector activity against ethanol-induced gastric lesions in wistar rats. Molecules 2013;18:11327-37. Aziba PI, Adedeji A, Ekor M, Adeyemi O. Analgesic activity of Peperomia pellucida aerial parts in mice. Fitoterapia 2001;72:57-8. Arrigoni Blank FM, Dmitrieva EG, Franzotti EM, Antoniolli AR, Andrade MR, Marchioro M. Anti-inflammatory and analgesic activity of Peperomia pellucida (L.) HBK (Piperaceae). J Ethnopharmacol 2004;91:215-8. Khan A, Rahman M, Islam S. Antipyretic activity of Peperomia pellucida leaves in rabbit. Turk J Biol 2008;32:37-41. Arrigoni Blank MF, Oliveira RLB, Mendes SS, Silva PA, Antoniolli AR, Vilar JC, et al. Seed germination, phenology, and antiedematogenic activity of Peperomia pellucida (L.) H. B. K. BMC Pharmacol 2002;2:12. Mutee AF, Salhimi SM, Yam MF, Lim CP, Abdullah GZ, Ameer OZ, et al. In vivo anti-inflammatory and in vitro antioxidant activities of Peperomia pellucida. Int J Pharmcol 2010;6:686-90. Khan MR, Omoloso AD. Antibacterial activity of Hygrophila stricta and Peperomia pellucida. Fitoterapia 2002;73:251-4. Akinnibosun HA, Akinnibosun FI, German BE. Antibacterial activity of aqueous and ethanolic leaf extracts of Peperomia pellucida (L.) H. B. and K. (Piperaceae) on three gram-negative bacteria isolates. Sci World J 2008;3:33-6. Wiart C, Mogana S, Khalifah S, Mahan M, Ismail S, Buckle M, et al. Antimicrobial screening of plants used for traditional medicine in the state of Perak, Peninsular Malaysia. Fitoterapia 2004;75:68-73. Oloyede GK, Onocha PA, Olaniran BB. Phytochemical, toxicity, antimicrobial and antioxidant screening of leaf extracts of Peperomia pellucida from Nigeria. Adv Environ Biol 2011;5:3700-9. Mensah JK, Ihenyen JO, Okhiure MO. Nutritional, phytochemical and antimicrobial properties of two wild aromatic vegetables from Edo State. J Nat Prod Plant Resour 2013;3:8-14. Igwe OU, Mgbemena NM. Chemical investigation and antibacterial activity of the leaves of Peperomia pellucida L. HBK (Piperaceae). Asian J Chem Pharm Res 2014;2:78-86. Uddin SB, Sultana R, Faruque O. Antibacterial activity of some selected medicinal plants used by the Rakhaing community of Cox’s Bazar district of Bangladesh. Academia J Microbiol Res 2014;2:21-7. Zubair KL, Samiya JJ, Jalal U, Mostafizur R. In vitro investigation of antdiarrhoeal, antimicrobial and thrombolytic activities of aerial parts of Peperomia pellucida. Pharmacologyonline 2015;3:5-13. Hastuti US, Ummah YPI, Khasanah HN. Antifungal activity of Piper aduncum and Peperomia pellucida leaf ethanol extract against Candida albicans. AIP Conference Proceedings 2017;1844:020006-1–020006-4. Doi.org/10.1063/1.4983417. Humzah RU, Odetola AA, Erukainure OL, Oyagbemi AA. Peperomia pellucida in diets modulates hyperglyceamia, oxidative stress and dyslipidemia in diabetic rats. J Acute Disease 2012;1:135-40. Beltran Benjamin KS, Co EL, Gaspi SAD, Matibag JLR, Su GLS. Enzyme activity and histopathology of rat liver treated with crude methanolic extract of Pepperomia pellucida (L.) HBK. J Biol Sci 2013;13:183-95. Phongtongpasuk S, Poadang S. Extraction of antioxidants from Peperomia pellucida L. Kunth. Thammasat Int J Sci Technol 2014;19:38-43. Ong S, Van SP, Lai H, Rao NK. In vitro lipase inhibitory effect of thirty two selected plants in Malaysia. Asian J Pharm Clin Res 2014;7:19-24. Parawansah, Nuralifah, Alam G, Natzir R. Inhibition of xanthine oxidase activity by ethanolic extract of Peperomia pellucida L., Acacypha indica L. and Momordica charantia L. Indonesian Biomed J 2016;8:161-6. Putri CA, Kartika GAA, Adnyana K. Preventive effect of Peperomia pellucida (L.) Kunth herbs on ovariectomy-induced osteoporotic rats. J Chin Pharm Sci 2016;25:546-51. Ebenezer OA, Kenneth E, Monday BB, Hilda MO. Fibrinolytic activity of some Nigerian medicinal plants. J Pharm Pharmacol 2014;2:177-84. Kanedi M, Lande ML, Nurcahyani N, Anggraeni IR, Yulianty. Hair-growth promoting activity of plant extracts of suruhan (Peperomia pellucida) in rabbits. IOSR J Pharm Biol Sci 2017;12:18-23. Ooi D, Iqbal S, Ismail M. Proximate composition, nutritional attributes and mineral composition of Peperomia pellucida L. (Ketumpangan Air) grown in Malaysia. Molecules 2012;17:11139-45. About this article Title ETHNOBOTANICAL USES, PHYTOCHEMISTRY AND PHARMACOLOGICAL ACTIVITIES OF PEPEROMIA PELLUCIDA (L.) KUNTH (PIPERACEAE)-A REVIEW Keywords Peperomia pellucida (L.) Kunth, Ethnomedicine, Traditional medicine, Phytochemical, Pharmacological activities DOI 10.22159/ijpps.2018v10i2.23417 Date 01-02-2018