Volume 77, 23 December 2015, Pages 196–203
- a Department of Pharmacognosy, Faculty of Pharmacy, Yeditepe University, 34755 Ataşehir, Istanbul, Turkey
- b Department of Pharmacognosy and Chemistry of Natural Products, School of Pharmacy, University of Athens,15771 Panepistimiopolis, Zografou, Athens, Greece
- c Laboratory of Pharmacognosy, School of Pharmacy, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
- d Department of Pharmaceutical Chemistry, School of Pharmacy, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
- Received 6 April 2015, Revised 10 August 2015, Accepted 11 August 2015, Available online 8 September 2015
Highlights
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- All Scutellaria species mainly S. hastifolia displayed marked total antioxidant capacity.
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- S. hastifolia MeOH extract significantly inhibited LOX enzyme at 5 mg/mL.
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- A new cornoside derivative phenylethanoid glycoside was isolated from S. hastifolia.
Abstract
This study was designed to evaluate the phenolic profiles and antioxidant potentials of different solvent extracts of four Scutellaria L. (Lamiaceae) taxa, S. hastifolia, S. velenovskyi, S. albida ssp. albida and S. orientalis ssp. pinnatifida, which are used in traditional medicines for various purposes. Among the investigated species, S. hastifolia
was selected for further biological and phytochemical studies according
to the results of preliminary screening assays. Phytochemical studies
on S. hastifolia yielded a new phenylethanoid glycoside
(hastifolioside) together with 16 known metabolites. The structures of
the compounds were established on the basis of spectroscopic analyses.
The antioxidant potentials and the antiinflammatory activities of the
crude extracts of S. hastifolia as well as the isolates were
evaluated through DPPH radical scavenging capability, linoleic acid
lipid peroxidation inhibition and soybean LOX inhibition assays.
Keywords
- Scutellaria hastifolia;
- Antioxidant and antiinflammatory activities;
- Secondary metabolites;
- Phenylethanoid glycosides;
- Hastifolioside
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