- a Department of Pharmacognosy, Faculty of Pharmacy, Yeditepe University, 34755 Ataşehir, Istanbul, Turkey
- b Department of Pharmacognosy and Chemistry of Natural Products, School of Pharmacy, University of Athens,15771 Panepistimiopolis, Zografou, Athens, Greece
- c Laboratory of Pharmacognosy, School of Pharmacy, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
- d Department of Pharmaceutical Chemistry, School of Pharmacy, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
- Received 6 April 2015, Revised 10 August 2015, Accepted 11 August 2015, Available online 8 September 2015
- All Scutellaria species mainly S. hastifolia displayed marked total antioxidant capacity.
- S. hastifolia MeOH extract significantly inhibited LOX enzyme at 5 mg/mL.
- A new cornoside derivative phenylethanoid glycoside was isolated from S. hastifolia.
This study was designed to evaluate the phenolic profiles and antioxidant potentials of different solvent extracts of four Scutellaria L. (Lamiaceae) taxa, S. hastifolia, S. velenovskyi, S. albida ssp. albida and S. orientalis ssp. pinnatifida, which are used in traditional medicines for various purposes. Among the investigated species, S. hastifolia was selected for further biological and phytochemical studies according to the results of preliminary screening assays. Phytochemical studies on S. hastifolia yielded a new phenylethanoid glycoside (hastifolioside) together with 16 known metabolites. The structures of the compounds were established on the basis of spectroscopic analyses. The antioxidant potentials and the antiinflammatory activities of the crude extracts of S. hastifolia as well as the isolates were evaluated through DPPH radical scavenging capability, linoleic acid lipid peroxidation inhibition and soybean LOX inhibition assays.
- Scutellaria hastifolia;
- Antioxidant and antiinflammatory activities;
- Secondary metabolites;
- Phenylethanoid glycosides;
Copyright © 2015 Elsevier B.V. All rights reserved.