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Monday, 30 November 2015

New Microsoft trade-in deal will give you up to $300 for your old MacBook

New Microsoft trade-in deal will give you up to $300 for your old MacBook or http://www.pcworld.com/article/2993502/laptop-computers/new-microsoft-trade-in-deal-will-give-you-up-to-300-for-your-old-macbook-or-laptop.html via @pcworld
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ANTIMICROBIAL AND ANTHELMINTIC ACTIVITY OF ELEUSINE INDICA

F.N.I. Morah, M.E. Otuk
Antimicrobial and anthelmintic activity of Elecusine indica
      Abstract   Full text (PDF)
 Antimicrobial activity of Elusine indica was carried out using Agar well diffusion method on selected pathogens usually associated with diarrhea or other stomach problems such as Shigella dysenteriae Escherichia coli, Salmonella typhi, Staphylococcus aureus, Streptococcus facealis and Lactobacillus lactis. The aqueous extract was the most susceptible while the ethanol extract was the least susceptible to these microorganisms. The observed antimicrobial activity is concentration dependent. The work also shows that the plant has marked anthelmintic activity against Strongyloides stercoralis. The work therefore gives credence to the use of Eleusine indica against diarrhea and worm infections.

Keywords: Eleusine indica, antimicrobial activity, anthelmintic activity, Strongyloides Stercorais

http://actaint.com/form.php?go=ci
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Anticancer bioactivity of compounds from medicinal plants used in European medieval traditions

Biochemical Pharmacology
Volume 86, Issue 9, 1 November 2013, Pages 1239–1247
Commentary

Anticancer bioactivity of compounds from medicinal plants used in European medieval traditions

  • a Laboratoire de Biologie Moléculaire et Cellulaire du Cancer, Hôpital Kirchberg, L-2540 Luxembourg, Luxembourg
  • b Department of Pharmacy, College of Pharmacy, Seoul National University, 599 Gwanak-ro, Gwanak-gu, Seoul 151-742, South Korea
Received 1 May 2013, Accepted 6 August 2013, Available online 20 August 2013

doi:10.1016/j.bcp.2013.08.007
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Abstract

Since centuries, natural compounds from plants, animals and microorganisms were used in medicinal traditions to treat various diseases without a solid scientific basis. Recent studies have shown that plants that were used or are still used in the medieval European medicine are able to provide relieve for many diseases including cancer. Here we summarize impact and effect of selected purified active natural compounds from plants used in European medieval medicinal traditions on cancer hallmarks and enabling characteristics identified by Hanahan and Weinberg. The aim of this commentary is to discuss the pharmacological effect of pure compounds originally discovered in plants with therapeutic medieval use. Whereas many reviews deal with Ayurvedic traditions and traditional Chinese medicine, to our knowledge, the molecular basis of European medieval medicinal approaches are much less documented.

Graphical abstract

Image for unlabelled figure

Keywords

  • Natural compounds;
  • Cancer hallmarks;
  • Inflammation signaling;
  • Cell cycle;
  • Cell death;
  • Immune system;
  • Tumor microenvironment

Corresponding author. Tel.: +82 2 880 8919.
Copyright © 2013 Elsevier Inc. All rights reserved.
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1929 Joan Ganz Cooney, television executive, founder of the Children’s Television Workshop and mastermind behind Sesame Street.

Annals of Global Health
Volume 81, Issue 1, January–February 2015, Pages 107–108
Consortium of Universities for Global Health: Poster Abstracts from the 6th Annual CUGH Conference
Consortium of Universities for Global Health: Mobilizing Resesarch for Global Health
Open Access

Sesame street in the tea estates: A multi-media intervention to improve sanitation and hygiene among Bangladesh's most vulnerable youth

Under a Creative Commons license

doi:10.1016/j.aogh.2015.02.748
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Background

Children growing up in Bangladesh's Sylhet Division are some of the world's most vulnerable youth. While this region is home to over 150 lush tea estates, workers and their families living in the area's densely-populated slums lack basic resources, such as clean water and latrines. Diarrhea remains a leading cause of childhood morbidity and mortality. In Spring 2014, Sesame Workshop and its local production team Sisimpur developed a multi-media intervention to improve health and hygiene knowledge, attitudes and behaviors among children and parents living in Sylhet. A research study was conducted to examine the most effective way to deliver these health communication messages.

Methods

A twelve week intervention occurred in Bhurbhuria, Bhararura, and Satgaon (similar communities within the Sylhet Division). Two approaches were created. The “me” approach framed messages and activities as personal, such that engaging in hygiene and sanitation behaviors would result in stronger and healthier individuals (delivered in Bhurbhuria). The “we” approach addressed hygiene and sanitation behaviors as community and social endeavors (Bhararura). Participants from Satgaon served as a control. Immediately before and after the intervention, 240 children (ages 3 to 8 years) and one of their parents completed one-on-one interviews. Active consent was used and the University of Maryland's IRB evaluated and approved the study protocols and instruments.

Findings

The interventions resulted in improvements in terms of hygiene and sanitation. Those receiving the “me” approach had stronger and statistically significant gains compared to those receiving the “we” approach for: Reported latrine use (based on child reports); “all of the time” hand-washing after defecation (parent reports); better understanding of tippy taps (parent reports); awareness of Sisimpur characters (child reports); and identifying behaviors depicted in the intervention materials (child reports). In contrast, members of the “we” approach did better than “me” approach for: Favorable attitudes of sanitation and hygiene behaviors (child reports); using an improved ventilated pit latrine at home (child reports); wearing shoes “all the time” (child reports); and using a tippy tap (child reports).

Interpretation

The Sisimpur interventions led to positive changes in hygiene and sanitation knowledge, attitudes and behaviors; multi-media approaches improved latrine use, shoe-wearing and hand-washing among young children from Sylhet. Because gains occurred with both approaches, the “we” approach was better as most participants felt the interventions' goals were to improve health and behaviors of all children in the community. While there were challenges and it is unknown how long the interventions’ impact will last, this work suggests that a hygiene and sanitation intervention can lead to improved outcomes with an extremely vulnerable population.

Funding

This research was supported by the Bill & Melinda Gates Foundation.

Abstract #

01SEDH005
Copyright © 2015 Published by Elsevier Inc
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1874 Winston Churchill, British prime minister during and after World War II.

1937   Sir Ridley Scott, English film director and producer; (Blade Runner, Thelma & Louise) won a Best Picture Oscar for Gladiator (2000).

 https://www.academia.edu/380334/_Maximus_Melodramaticus_Masculinity_Masochism_and_White_Male_Paranoia_in_Contemporary_Hollywood_Cinema_
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1835 Mark Twain (Samuel Langhorne Clemens), American writer best remembered for The Adventures of Tom Sawyer and The Adventures of Huckleberry Finn.

Mark Twain & the Boyhood that Inspired His Classics http://www.biography.com/news/mark-twain-early-life-facts
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1667 Jonathan Swift, English satirist who wrote Gulliver’s Travels.

History of European Ideas
Volume 31, Issue 2, 2005, Pages 147–171
Instruments of Enlightenment

The trickster as an instrument of enlightenment: George Psalmanazar and the writings of Jonathan Swift ☆

Choose an option to locate/access this article:

doi:10.1016/j.histeuroideas.2003.11.004
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Abstract

The publication of George Psalmanazar's Description of Formosa (1704–1705) and the controversy surrounding the young man who claimed to be ‘a Native of Formosa, An Island subject to the Emperor of Japan,’ must place text and author among the most audacious examples of literary fraud in any language. Psalmanazar's Formosa fabrications—including claims of endemic polygamy, cannibalism, and child sacrifice—titillated and appalled his contemporaries, including Jonathan Swift, who paid mock tribute to the ‘famous Salmanaazor’ in A Modest Proposal (1729), crediting the ‘Formosan’ with being the true genius behind the plan ‘for preventing the children of poor people in Ireland, from being a burden on their parents or country’. Little attention has been paid to the possibility that Psalmanazar may have been a source for other Swift satires, including the little-known An Account of the Court and Empire of Japan (1727–1728), and major texts such as Gulliver’s Travels (1726). This essay aims to bring the image of one of the 18th century's more entertaining personalities into sharper resolution, and to explore the possibility that his influence on Swift was greater than has been generally suspected.
☆
While gathering research materials used in this paper, I was allowed generous access to rare books and facilities at the Bancroft Library at the University of California at Berkeley, the Ethnology Library at Academia Sinica in Nankang, and most recently Newcastle University in the UK. I wish to acknowledge the helpful scholars and staff at all three institutions.

Department of English Literature, C/o University of Sheffield, Shearwood Mount Shearwood Road, Sheffield S10 2TN, UK. Tel.: +44-114-268-4402; fax: +44-114-2228-452
Copyright © 2004 Elsevier Ltd. All rights reserved.
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1982 Thriller, Michael Jackson’s second solo album, released; the album, produced by Quincy Jones, became the best-selling album in history.

Commentary

Frederic Chopin and Michael Jackson: What could they have in common?

Frédéric Chopin et Michael Jackson : qu’ont-ils en commun ?
  • S. Erlinger, 
  •  
  • http://www.em-consulte.com/en/article/256843 


  • June 25, 2009: death of a King
    One hundred and fifty years after Chopin’s death, another music star dies, with, allegedly, the same hereditary disease. For the hundreds of thousands of fans of Michael Jackson, a dramatic event takes place on June 25, 2009. On that day, the “King of Pop” dies, according to the official report of autopsy, of “acute propofol intoxication”, an anaesthetic agent used by his personal physician to facilitate sleep. This practitioner who injected propofol will have to justify himself before the justice of his country.
    But, apart from chronic anxiety and sleep problems, vitiligo and other complaints, the pop star might also have suffered from ⍺ 1 -AT deficiency. In December 2008, one can read in the press that Michael Jackson has ⍺ 1 -AT deficiency and that his life expectancy does not exceed a few months [16]. In a biography published soon after his death, the journalist and investigator Ian Halperin (who is at the origin of the rumour diffused by the press in December) alleges again that Jackson has had this disease for several years and was actually on a waiting list for lung transplantation [17]. The author claims that a physician who took care of the respiratory problems of Michael Jackson, and who accepted to answer his questions, confirmed the diagnosis. This allegation raised considerable emotion throughout the world. In fact, there is little evidence to support this hypothesis. Michael had eight brothers and sisters and none is known to have a chronic respiratory disease. The singer displayed considerable energy on stage during his professional career, starting at the age of 11 years, an observation hardly compatible with a long-standing chronic disease. And finally, the autopsy report does not mention any major abnormality either of the bronchopulmonary system or of the liver [18], the two main targets of ⍺ 1 -AT deficiency.
    In conclusion, there is convincing evidence, although not conclusive at this time, that one of the greatest composers of the 19th century, Frederic Chopin, suffered from ⍺ 1 -AT deficiency. Many musicologists even argue that this long-lasting and devastating disease, which made Chopin conscious that he would probably not live a long life, probably accounts for the dramatic character of many of his works. In contrast, the allegation that Michael Jackson, one of the most popular artists of the 20th century, also had ⍺ 1 -AT deficiency should at this time be taken with great caution. Recently, a DNA analysis was performed on the mummy of Tutankhamun, the Egyptian pharaoh [19]. Since he died circa 1324 BC, some 34 centuries ago, why not consider performing such an analysis on Chopin’s heart and on Jackson’s tissues taken at autopsy, so that future historians of music have a definite answer to these medical mysteries.
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1919 Women cast votes for the first time in French legislative elections.

Economics Letters
Volume 133, August 2015, Pages 27–30

Gender contributions to income inequality


doi:10.1016/j.econlet.2015.05.009
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Highlights

•
Determine the contribution of gender to wage inequality from the Shapley approach.
•
Decompose inequality by considering gender as an income source.
•
Measure gender inequality in the light of all the wage distribution.
•
A decomposition applicable regardless of the index used to measure inequality.

Abstract

This note suggests a new way of determining the contribution of gender to wage inequality as part of the framework based on the Shapley approach. The proposed methodology is illustrated using French data over the period 1970–2003.

JEL classification

Keywords

  • Shapley value;
  • Inequality decomposition;
  • Gender

Corresponding author at: CREM-CNRS, University of Caen Basse-Normandie, MRSH, Esplanade de la Paix, 14032 Caen cedex, France.
Copyright © 2015 Elsevier B.V. All rights reserved.
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Use and importance of quina (Cinchona spp.) and ipeca (Carapichea ipecacuanha (Brot.) L. Andersson): Plants for medicinal use from the 16th century to the present

Journal of Herbal Medicine
Volume 2, Issue 4, December 2012, Pages 103–112
Review


doi:10.1016/j.hermed.2012.07.003
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Abstract

Observations in prescriptions of the monasteries’ apothecaries of São Bento from Rio de Janeiro (Rio de Janeiro) and Olinda (Pernambuco) dating from the nineteenth century, prescribed quina (Cinchona spp., Rubiaceae) and ipeca (Carapichea ipecacuanha [Brot.] L. Andersson, Rubiaceae) for antidiarrheal/febrifuge and emetic/expectorant uses. In addition to these observations, pharmacological and anthropological literature indicate a great importance of using these plants for treating human diseases since ancient times. From this information, the present work conducts a literature review to investigate the history of discovery and use of these species, recovering information about past and current uses of quina and ipeca, seeking also to record possible changes in usage over time.

Keywords

  • Historical ethnobotany;
  • Rubiaceae;
  • Past pharmacopoeias

Corresponding author.
Copyright © 2012 Elsevier GmbH. All rights reserved.
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Contribución de la Agencia Española de Medicamentos y Productos Sanitarios al Comité Europeo de Evaluación de Medicamentos de Uso Humano

Revista Clínica Española (English Edition)
Volume 215, Issue 4, May 2015, Pages 230–235
Special article

Contribution of the Spanish Agency for Medicines and Healthcare Products to the European Committee for the Evaluation of Medicinal Products for Human Use ☆

Contribución de la Agencia Española de Medicamentos y Productos Sanitarios al Comité Europeo de Evaluación de Medicamentos de Uso Humano ☆

doi:10.1016/j.rceng.2014.12.002
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Refers To
  • A. Alonso-Gutiérrez, P. Díaz-Ramos, E. Sulleiro-Avendaño, M. de Miguel-Marañón, M.E. Padilla-Gallego, A. Sancho-López, S. Ruiz-Antúnez, C. Prieto-Yerro

  • Revista Clínica Española, Volume 215, Issue 4, May 2015, Pages 230-235

Abstract

The centralized procedure for registering medicinal products involves a joint assessment by all regulatory agencies of European Union member states, which are coordinated by the European Medicines Agency. Since its implementation in 1995, the Spanish Agency for Medicines and Healthcare Products (AEMPS) has actively contributed to the committee on medicinal products for human use. The therapeutic areas in which AEMPS has the greatest presence are cardiovascular, sensory organs (mainly ophthalmology) and genitourinary/sexual hormones. The technical staff of AEMPS contribute their expertise and extensive experience to this task, as do the practitioners of the Spanish healthcare system who act as external experts, providing their clinical vision and bringing the daily clinical practice to the evaluation of medicinal products. As with other European decision spaces, the joint participation of the member states is not homogeneous, with a minority of countries still heading the majority of assessments for the committee on medicinal products for human use, although all member countries take part in the final decision.

Resumen

El procedimiento de registro de medicamentos centralizado implica una evaluación conjunta por todas las Agencias Reguladoras de los Estados miembros de la Unión Europea que es coordinada por la Agencia Europea de Medicamentos. Desde su implantación en 1995, la Agencia Española de Medicamentos y Productos Sanitarios (AEMPS) ha contribuido de forma activa al Comité de medicamentos de uso humano. Las áreas terapéuticas en las que la AEMPS tiene más presencia son cardiovascular, órganos de los sentidos (fundamentalmente oftalmología) y genitourinario-hormonas sexuales. A esta labor contribuyen con sus conocimientos y su extensa experiencia los técnicos de la propia AEMPS así como profesionales del sistema sanitario español que actúan en calidad de expertos externos aportando su visión clínica y acercando la práctica diaria a la evaluación de medicamentos. Como sucede con otros espacios de decisión europeos, la participación del conjunto de Estados miembro no es homogénea siendo todavía una minoría de países los que lideran la mayoría de las evaluaciones del Comité de medicamentos de uso humano, aunque todos los países toman parte en la opinión final.

Keywords

  • AEMPS;
  • CHMP;
  • EMA;
  • Medicinal products for human use;
  • Centralized procedure

Palabras clave

  • AEMPS;
  • CHMP;
  • EMA;
  • Medicamentos de uso humano;
  • Procedimiento centralizado
☆
Please cite this article as: Alonso-Gutiérrez A, Díaz-Ramos P, Sulleiro-Avendaño E, de Miguel-Marañón M, Padilla-Gallego ME, Sancho-López A, et al. Contribución de la Agencia Española de Medicamentos y Productos Sanitarios al Comité Europeo de Evaluación de Medicamentos de Uso Humano. Rev Clin Esp. 2015;215:230–235.

Corresponding author.
Copyright © 2015 Elsevier España, S.L.U. and Sociedad Española de Medicina Interna (SEMI). All rights reserved.
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1900 Oscar Wilde dies in a Paris hotel room after saying of the room’s wallpaper: "One of us had to go."

Procedia - Social and Behavioral Sciences
Volume 158, 19 December 2014, Pages 33–36
14th Language, Literature and Stylistics Symposium
Open Access

Slaves and Masters of Words: Conformism of the Sexual Martyr ☆

Under a Creative Commons license

doi:10.1016/j.sbspro.2014.12.029
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Abstract

Oscar Wilde was an author who resisted the social norms of his time. We can see several instances when he showed resistance, but when we read his works, we can still see the sense of duty that overwhelmed Victorian life. So it is crucial to examine what he did in his works while he became a kind of sexual martyr in his own life. Language is a social device which is used to think and express ourselves. The way in which Oscar Wilde presents his thoughts is interesting since he presents a dilemma. His work, The Crime of Lord Arthur Savile which I am going to examine in my paper, is about a man who tries to murder people in the name of a gendered duty and who gets away with it. With both direct and indirect use of words, Wilde creates a world of morality and duty like a conformist. Direct speech versus action way of language use shows us the direct relation between language, power and knowledge. While the power which holds the language in its hands gives the orders, everyday Victorian man abides by it with his/her actions.
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Instituut Voor Etnobotanie En Zoofarmacognosie contributions

1. IEZ contributions - 2 reports written in 2012 for the Praktijknetwerken Varkens bioberen (Pigs) and Konijnen antibioticavermindering (rabbits). 

2012. Asseldonk, A.G.M. van. De inzet van kruiden om agressie bij mannelijke ongecastreerde
varkens te verminderen. IEZ, Beek (rapport20120801 tbv Project antibioticavermindering in de
biologische varkenshouderij).
 
2. contributed to Praktijknetwerk Voederbomen. Available on internet (coordinator Nick v Eekeren from Louis Bolk Inst). http://www.voederbomen.nl/wordpress/wp-content/uploads/2012/04/Medicinale-en-etnobotanische-aspecten-van-potenti%C3%ABle-voederbomen-voor-melkvee.pdf


3. 2010-2011 worked on a project with the Louis Bolk Institute on a project about medicinal herbs in pastures, helping Sibilla Laldi who did the research http://www.louisbolk.org/downloads/2681.pdf

http://www.ema.europa.eu/docs/en_GB/document_library/contacts/tvanasseldonk_CV.pdf
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Sunday, 29 November 2015

End the violence: the women's rights defenders killed in 2015

| Liz Ford and Nana Darkoa Sekyiamah http://gu.com/p/4eezh/stw
..................................................................................................................

UBC Graduate Student Society launches confidential harassment reporting website http://www.news1130.com/2015/11/28/ubc-graduate-student-society-launches-confidential-harassment-reporting-website/ via @NEWS1130


UBC featured in the fifth estate

If you are a manager of staff whose work is not computer-based, please print this email and display it in a common work area for them to review.
You may have seen media coverage, regarding UBC being featured in the fifth estateprogram about sexual assault and harassment on university campuses. We admire the courage of the women who came forward to bring attention to this crucial issue.
I want to apologize to the women in these cases who feel they have been let down by our university. While the university had to wait until it had the necessary facts to take action, I acknowledge that the process took too long. Due process can be frustrating and time-consuming. However, the university reached an appropriate conclusion. As an institution, we are committed to justice for the survivors of sexual assault.
I appreciate the light the women have shone on this issue, and I want to make a pledge. We will begin a discussion with our students, faculty and staff on a separate sexual assault policy that will enable the university to take action in a more timely and effective manner.
We will be reviewing the steps that were taken in these cases to determine how they might have been handled more effectively and expeditiously. As an institution, we are constantly looking at ways to improve our processes to make them more responsive and effective.
We recognize that sexual assault can happen to anyone – not just our students. Support resources for faculty and staff are available athttp://www.hr.ubc.ca/health/safety/sexual-assault-resources/.
In addition, you can find general resources to support your safety on campus athttp://faculty-staff.ubc.ca/2015/11/10/campus-safety-resources/.
Finally, let me be clear – sexual violence is unacceptable and is not tolerated at UBC. Students who have been found to have committed sexual assault following due process will be expelled from the university. Staff or faculty members who have been found to have committed sexual assault following due process will be terminated.
Martha C. Piper
Interim President and Vice-Chancellor

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Complementary and Alternative Medicine Use Among Cancer Patients and Determination of Affecting Factors: A Questionnaire Study

Holist Nurs Pract. 2015 Nov-Dec;29(6):357-69. doi: 10.1097/HNP.0000000000000113.


Üstündağ S1, Demir Zencirci A.

Author information

Abstract

This descriptive and cross-sectional study was conducted to determine the use and effects of complementary and alternative medicine on cancer patients receiving chemotherapy. The research was conducted in Daytime Chemotherapy Unit of the College District Outpatients in the Ankara Numune Education and Research Hospital and comprised 397 patients in the oncology outpatients. Written informed consents were obtained from all participants. Among the participants, 52.6% were women, 85.1% married, 10.6% illiterate, 41.1% housewife, and 8.8% civil servants. Among the patients participated in the study, 27.7% had cancer in the family, 22.6% had gastrointestinal cancer, and 22.1% had breast cancer. Most of the patients (92.2%) resorted to religious and cultural approaches, and some patients (33.8%) used nutritional and herbal products besides medical treatment. The nutritional and herbal products used as remedy included stinging nettle (22.3%), fennel flower (20.1%), and herbal products that were advertised by herbalists in media (9.7%). It was determined that most of the patients resorting to complementary or alternative medicine were women (52.6%), housewife (51.5%), and patients with a history of cancer in the family (37.7%). Complementary and alternative medicine use as a remedy for cure is common among patients in Turkey. But when it is considered that many of these products had the potential to negatively affect cancer therapy, it is crucial that nurses providing care to cancer patients should be well informed about complementary therapies, be aware of the potential risks and benefits, and communicate openly with patients on their health care choices.
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Hypericum perforatum use during pregnancy and pregnancy outcome

Reprod Toxicol. 2015 Nov 1;58:234-237. doi: 10.1016/j.reprotox.2015.10.003. [Epub ahead of print]

Hypericum perforatum use during pregnancy and pregnancy outcome.

Kolding L1, Pedersen LH2, Henriksen TB3, Olsen J4, Grzeskowiak LE5.

Author information

Abstract

Hypericum perforatum (HP; also known as St. John's Wort) is one of the most commonly used herbal therapies in the management of depressive illness. The aim of this study was to evaluate the potential side effects of HP during pregnancy on pregnancy outcome. Using data from the Danish National Birth Cohort (DNBC), we investigated outcomes among 38 HP exposed pregnancies compared to a group of 90,128 women. Associations between HP use and gestational age, preterm birth, birth weight, malformations and Apgar scores were investigated. Preterm birth did not differ across the groups. While the prevalence of malformations in the HP exposed group was slightly higher (8.1%) than observed in the control groups (3.3%; p=0.13), this was based on only three cases and was not of any specific pattern.
Copyright © 2015 Elsevier Inc. All rights reserved.

KEYWORDS:

Birth outcomes; Human pregnancy; Hypericum perforatun; Malformations; St. John’s Wort
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1907: Minnie, the Thanksgiving Cat of the Essex Market Police Court Prison

http://wp.me/p35yDk-k7 via @HatchingCatNYC
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Director's Page Josephine P. Briggs, M.D. Wellness Versus Treatment: The Reasons Why People Choose Complementary Health Approaches

http://nccih.nih.gov/about/offices/od/wellness-vs-treatment via @NIH_NCCIH
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Disparities in access to effective treatment for infertility in the United States: an Ethics Committee opinion.

Fertil Steril. 2015 Nov;104(5):1104-10. doi: 10.1016/j.fertnstert.2015.07.1139. Epub 2015 Sep 10.


Ethics Committee of the American Society for Reproductive Medicine.

Abstract

In the United States, economic, racial, ethnic, geographic, and other disparities exist in access to fertility treatment and in treatment outcomes. This opinion examines the factors that contribute to these disparities and proposes actions to address them.
Copyright © 2015 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
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Network Pharmacology and Natural Products


Date: 
December 2, 2015 - 1:00p.m. ET to 3:45p.m. ET
Location: 
Webinar

Event Description

NCCIH will hold a webinar on the topic of network pharmacology and natural products.  The purpose of the webinar is to discuss new technology that has the potential to elucidate how natural products impact biological networks. The Center is seeking input on focus areas to strengthen NCCIH’s natural products research portfolio.

Background

People consume a wide variety of natural products daily either through their diet or via dietary supplements. Individually and collectively, these compounds act on a wide range of biological targets with varying degrees of potency. Recent literature suggests that pharmaceuticals designed to be highly selective toward single targets may sometimes be less effective than multitarget drugs due to the phenotypic robustness of many biological systems. Because of this phenotypic robustness, it may be necessary to perturb multiple points in a biological pathway in order to elicit the desired response. The term “network pharmacology” has been coined to describe the web of biologic targets for any bioactive substance and has emerged as a new transdisciplinary field of research in the omics era.

Webinar Discussion Points

  1. How can the strategies of network pharmacology applied to natural products provide:
    • Better understanding of the overlapping biologic pathways and targets that result in development and persistence of chronic conditions (especially pain)?
    • Characterization of natural products, either known or novel, singly or in combination, with potential to modulate biological networks?
  2. What are the factors to consider when applying this approach to specific conditions versus more agnostic and “exploratory” topics including developing broader data sets of bio-activity for a large array of natural products (e.g. LINCS)?
  3. Tools to unravel complex mechanisms of action for natural products.
  4. How can these techniques help identify “biologic signatures” that might ultimately be helpful in clinical studies of natural products?
  5. Barriers for implementation in the natural products community.
  6. Considering the requirements of expertise and resources along the continuum from single omics to multi omics through multi-scale, systems level modeling, where is the field of natural products research best positioned to make significant advances as it relates to network pharmacology?

Expected Outcome

NCCIH seeks input from experts in the field and stakeholders to determine how new tools and approaches allow for better understanding of network pharmacology, and with potentially greater sensitivity to detect the subtle effects often attributed to natural products. NCCIH has an interest in learning how these powerful bioinformatic tools can be applied to the study of natural products. The expectation is that leveraging these tools towards research on natural products will provide a more complete picture regarding their mechanism of action (i.e., a biological signature) than is achieved through the more standard practice of studying natural products in single target assays

Speakers

Guido F. Pauli, Pharm.D., Ph.D. (Meeting Chair)
Professor, Department of Medicinal Chemistry and Pharmacognosy
College of Pharmacy, University of Illinois at Chicago
Peter Sorger, Ph.D.
Otto Krayer Professor, Department of Systems Pharmacology
Head of the Harvard Program in Therapeutic Sciences - HiTS
Harvard Medical School
John MacMillan, Ph.D.
Associate Professor
Chilton/Bell Scholar in Biochemistry, Department of Biochemistry
University of Texas Southwestern Medical Center
Roger Linington, Ph.D.
Associate Professor
Canada Research Chair in High-Throughput Screening and Chemical Biology
Department of Chemistry
Simon Fraser University (Canada)

Registration

Please register to participate via Webex on December 2, 2015. After your request has been approved, you'll receive instructions for joining the webinar. If you already registered for this meeting, you do not need to register again.
If you have questions, please contact Dr. Julia Berzhanskaya.

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Free Webcast: Classic Career Mistakes and How to Avoid Them

HigherEdJobs - Aspire Higher
Free Webcast: Classic Career Mistakes and How to Avoid Them 

We're all human and it's impossible to go through an academic career without tripping up a time or two. The important thing is to learn from mistakes and to recover as nobly as one can. 

During this webcast, Sheila Murphy, an experienced higher ed recruiter and long-time student affairs officer, discusses common yet serious mistakes that higher ed professionals make - from job search failures to burning bridges to CV flaws. She provides unique insight into these issues and shares advice on how to avoid these mistakes if possible, and what to do when, inevitably, a career blunder happens. 

Watch Now

If you have any questions or comments, please contact us at webinar@higheredjobs.com.
 
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Evaluation of efficacy of a commercially available herbal mouthwash on dental plaque and gingivitis: A double-blinded parallel randomized controlled trial

ORIGINAL ARTICLE

Year : 2015  |  Volume : 13  |  Issue : 3  |  Page : 222-227


Sanjukta Bagchi, Sabyasachi Saha, GV Jagannath, Vamsi Krishna Reddy, Pooja Sinha
Department of Public Health Dentistry, Sardar Patel Post Graduate Institute of Dental and Medical Sciences, Lucknow, Uttar Pradesh, India
Date of Web Publication14-Sep-2015
    
Correspondence Address:
Sanjukta Bagchi
Department of Public Health Dentistry, Sardar Patel Post Graduate Institute of Dental and Medical Sciences, Lucknow, Uttar Pradesh 
India
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2319-5932.165210
  Abstract 
Aim: To evaluate if a commercially available herbal mouthwash, can be a better choice as an anti-plaque and antigingivitis agent when compared with chlorhexidine. Materials and Methods: In a double-blind, parallel group randomized clinical trial 90 nursing students aged 18-25 years were randomly divided into three groups: A (chlorhexidine), B (HiOra) and C (distilled water). These groups were asked to rinse with their respective mouthwash two times daily for 21 days. Plaque and gingivitis were evaluated by using Turesky et al. modification of Quigley Hein Plaque Index (1970) and Modified Gingival Index by Lobene et al. (1986) respectively. Statistical analysis was done using ANOVA test. Results: There was statistically significant reduction in plaque and gingival scores from baseline to 21 days in both the groups A and B. Conclusions: Although chlorhexidine group proved to be the best anti-plaque and antigingivitis agent, it was found that HiOra group also showed gradual improvement from baseline to 21 days. Whereas no improvement was seen in the Group C using distilled water over 21 days.
Keywords: Anti-plaque agents, chlorhexidine, herbal mouthwash

How to cite this article:
Bagchi S, Saha S, Jagannath G V, Reddy VK, Sinha P. Evaluation of efficacy of a commercially available herbal mouthwash on dental plaque and gingivitis: A double-blinded parallel randomized controlled trial. J Indian Assoc Public Health Dent 2015;13:222-7

How to cite this URL:
Bagchi S, Saha S, Jagannath G V, Reddy VK, Sinha P. Evaluation of efficacy of a commercially available herbal mouthwash on dental plaque and gingivitis: A double-blinded parallel randomized controlled trial. J Indian Assoc Public Health Dent [serial online] 2015 [cited 2015 Nov 29];13:222-7. Available from: http://www.jiaphd.org/text.asp?2015/13/3/222/165210
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