Saturday, 28 November 2015

Analytical investigation of legal high products containing Salvia divinorum traded in smartshops and internet

Volume 242, September 2014, Pages 255-260

REQUIMTE, Laboratório de Toxicologia, Departamento de Ciências Biológicas, Faculdade de Farmácia, Universidade do Porto, Porto, Portugal


Lately, the hallucinogenic plant Salvia divinorum has been considered a popular recreational product among adolescents, being legally sold in several countries in "smartshops" and in internet websites. Sellers frequently omit the safety information about the plant, encouraging its use for recreational purposes, without providing adequate qualitative and quantitative details. The principal hallucinogenic compound of the plant, salvinorin A, alongside with three other isomeric compounds, salvinorin B, C and D were evaluated in 10 products containing S. divinorum. These products were obtained in smartshops and from internet websites, and contained concentrated extracts of salvinorin A, with potencies labeled between "5x" and "60x". For that purpose a simple and rapid extraction protocol and a GC-MS methodology were developed and applied to the purchased samples. The analysis of S. divinorum samples allowed the identification of four salvinorins, salvinorin A being the most prevalent hallucinogen. In the tested samples, there were several unreliable data provided to consumers. Frequently, there was no information on salvinorin A concentration, but when it existed, it generally did not correspond to the true amount present in products. On the other hand, the concentration of salvinorin A in each product far exceeded the amount needed to produce hallucinogenic effects. © 2014 Elsevier Ireland Ltd.

Author keywords

Legal drugs; Salvia divinorum; Salvinorin A; Smartshops

Indexed keywords

EMTREE drug terms: salvinorin A; salvinorin B; salvinorin C; salvinorin D; terpenoid; unclassified drug; clerodane derivative; diterpene; plant extract; psychedelic agent; salvinorin A; salvinorin B; salvinorin C; salvinorin D
EMTREE medical terms: analytic method; article; concentration (parameters); consumer health information; controlled study; Internet; marketing; mass fragmentography; priority journal; process development; quantitative analysis; Salvia divinorum; validation study; chemistry; commercial phenomena; drug labeling; human; mass fragmentography; Portugal; product safety; Salvia
MeSH: Commerce; Consumer Product Safety; Diterpenes; Diterpenes, Clerodane; Drug Labeling; Gas Chromatography-Mass Spectrometry; Hallucinogens; Humans; Internet; Plant Extracts; Portugal; Salvia
Medline is the source for the MeSH terms of this document.
Chemicals and CAS Registry Numbers: Diterpenes; Diterpenes, Clerodane; Hallucinogens; Plant Extracts; salvinorin A; salvinorin B; salvinorin C; salvinorin D
ISSN: 03790738 CODEN: FSINDSource Type: Journal Original language: English
DOI: 10.1016/j.forsciint.2014.07.009 PubMed ID: 25093918Document Type: Article
Publisher: Elsevier Ireland Ltd