Sunday, 21 February 2016

Treatment of nausea in pregnancy: A cross-sectional multinational web-based study of pregnant women and new mothers

December 01, 2015

Department of Global Public Health and Primary Care and Centre for Pharmacy, University of Bergen, Bergen
Pharmacoepidemiology and Drug Safety Research Group, Department of Pharmacy, School of Pharmacy, University of Oslo, Oslo
The Motherisk Program, Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, Toronto


Background: The factors related to the treatment of nausea during pregnancy have not yet been investigated in several countries simultaneously. The present study aimed to describe differences in self-reported nausea during pregnancy and the patterns of use for both conventional and herbal medicines across countries. The factors related to nausea and its treatment and the relationships between different self-reported co-morbidities and nausea were also investigated. Methods: This cross-sectional study used data collected by a web-based questionnaire distributed between October 2011 and February 2012 in several countries within five regions: Western, Northern, and Eastern Europe, North America, and Australia. Women who were pregnant or had a child less than one year old were eligible to participate. Results: A total of 9113 women were included in the study, whereof 6701 (73.5 %) had experienced nausea during pregnancy. Among respondents with nausea, conventional medicines were used by 1201 (17.9 %) women and herbal medicines by 556 (8.3 %) women. The extent of self-reported nausea and its treatment varied by country. Education, working status, and folic acid use were significantly associated with the use of conventional medicines against nausea. Respondents who had nausea also had a high burden of co-morbidity. Conclusion: The prevalence of nausea was high across all participating countries but its treatment varied, possibly due to cultural differences and differences in attitudes towards medicines. A high degree of co-morbidity was found among respondents with nausea. © 2015 Heitmann et al.

Author keywords

Herbal medicine; Internet; Multinational; Nausea; Pharmacotherapy; Pregnancy
ISSN: 14712393 CODEN: BPCMBSource Type: Journal Original language: English
DOI: 10.1186/s12884-015-0746-2Document Type: Article in Press
Publisher: BioMed Central Ltd.

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  Heitmann, K.; Department of Global Public Health and Primary Care and Centre for Pharmacy, University of Bergen, Bergen,
© Copyright 2015 Elsevier B.V., All rights reserved.