In this review, the potential pharmacological activities of Cyperus rotundus Linn. are evaluated along the foundation of literature survey. Being a world worst weed, the positive side of this plant having huge beneficial effects and here the beneficial side of this plant is highlighted which are used to treat different physiological conditions like stomach and bowel disorders, inflammatory diseases, and as traditional folk medicines. The extracts of different parts of the plant (aerial part, tuber, rhizomes, etc.) contain huge medicinal active compounds along with the chemical structures of the phytochemical constituents are included in this review.