Exposure to polybrominated diphenyl ethers and male reproductive function in Greenland, Poland and Ukraine

Reproductive Toxicology

Volume 43, January 2014, Pages 1–7

• Gunnar Toft^{a, ,} ,
• Virissa Lenters^b,
• Roel Vermeulen^b,
• Dick Heederik^b,
• Cathrine Thomsen^c,
• Georg Becher^{c, d},
• Aleksander Giwercman^e,
• Davide Bizzaro^f,
• Gian Carlo Manicardi^g,
• Marcello Spanò^h,
• Lars Rylanderⁱ,
• Henning S. Pedersen^j,
• Paweł Struciński^k,
• Valentyna Zviezdai^l,
• Jens Peter Bonde^m

• doi:10.1016/j.reprotox.2013.10.002

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Highlights

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BDE-47 and BDE-153 were detected in more than 97% of serum samples from 299 fertile men from Greenland, Poland and Ukraine.

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BDE-47 and BDE-153 were not associated to male semen quality, sperm DNA damage, apoptosis markers, or reproductive hormones.

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The results indicate that background PBDE exposure in Greenland, Poland and Ukraine is not affecting male fertility.

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Abstract

Animal and a few human studies suggest that polybrominated diphenyl ethers (PBDEs) may affect male reproductive function. The aim of the present study was to evaluate if male reproductive function was associated with serum level of PBDEs. We evaluated, in a cross-sectional study, the effects of environmental exposure to BDE-47 and BDE-153 on reproductive hormones and semen quality, including markers of DNA damage and apoptosis, in 299 spouses of pregnant women from Greenland, Poland and Ukraine. Adjusted linear regression models indicated no strong associations between BDE-47 or BDE-153 exposure and markers of male semen quality or reproductive hormones. In the largest study to date we demonstrate that BDE-47 and BDE-153 exposure was not associated with altered semen characteristics or reproductive hormones, indicating that male reproductive function is not affected by the exposure level of these compounds in fertile European or Arctic populations.

Keywords

• Semen quality;
• Reproductive hormones;
• Inhibin B;
• DNA damage;
• Apoptosis;
• PBDE;
• BDE-47;
• BDE-153

Corresponding author at: Danish Ramazzini Center, Department of Occupational Medicine, Aarhus University Hospital, Norrebrogade 44, Building 2C, 8000 Aarhus C, Denmark. Tel.: +45 78 46 4251; fax: +45 7846 4260.

Copyright © 2013 Elsevier Inc. All rights reserved.