Cumin (Cuminum cyminum L.) is a safe approach for management of lipid parameters: A systematic review and meta-analysis of randomized controlled trials.

Phytother Res. 2018 Nov;32(11):2146-2154. doi: 10.1002/ptr.6162. Epub 2018 Aug 8. Hadi A1, Mohammadi H2, Hadi Z3, Roshanravan N4, Kafeshani M1. Author information 1 School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. 2 Department of Clinical Nutrition, School of Nutrition & Food Science, Students' Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran. 3 Shohadaye Lenjan Hospital, Zarrin shahr, Isfahan, Iran. 4 Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Abstract We performed a meta-analysis to evaluate the efficacy of cumin supplementation on plasma lipid concentration in adult population. The search included PubMed, Scopus, ISI Web of Science, Google Scholar, and the Cochrane library (up to January 2018) to identify randomized controlled trials (RCTs) investigating the effects of cumin supplementation on serum lipid parameters. Mean difference (MD) was pooled using a random-effects model. Meta-analysis of data from six eligible RCTs with 376 participants showed a significant reduction in plasma concentration of total cholesterol (MD [95% CI] -10.90 [-21.39, -0.42] mg/dl, p = 0.042) and low-density lipoprotein cholesterol (MD [95% CI] -6.94 [-11.53, -2.35] mg/dl, p = 0.003) after supplementation with cumin compared with control treatment, and plasma concentration of high-density lipoprotein cholesterol (MD [95% CI] 3.35 [1.58, 5.12] mg/dl, p˂0.001) were found to be increased. Although our analysis indicated that cumin supplementation cannot change triglyceride (TG) concentration (MD [95% CI] -20.48 [-41.23, -0.26] mg/dl, p = 0.053), but after stratified the RCTs based on the primary level of TG (hypertriglyceridemia versus nonhypertriglyceridemia subjects), there was a significant decrease in nonhypertriglyceridemia subset. This systematic review and meta-analysis suggested the efficacy of cumin supplementation on lipid parameters. KEYWORDS: cumin; lipids; meta-analysis; randomized controlled trials PMID: 30088304 DOI: 10.1002/ptr.6162 [Indexed for MEDLINE]