"Benifuuki" Extract Reduces Serum Levels of Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Ligands Containing Apolipoprotein B: A Double-Blind Placebo-Controlled Randomized Trial.

Nutrients. 2018 Jul 19;10(7). pii: E924. doi: 10.3390/nu10070924. Miyawaki M1, Sano H2, Imbe H3, Fujisawa R4, Tanimoto K5, Terasaki J6, Maeda-Yamamoto M7, Tachibana H8, Hanafusa T9, Imagawa A10. Author information 1 Department of Internal Medicine (I), Osaka Medical College, 2-7 Daigaku-machi, Takatsuki 569-8686, Japan. in1295@osaka-med.ac.jp. 2 Department of Internal Medicine (I), Osaka Medical College, 2-7 Daigaku-machi, Takatsuki 569-8686, Japan. in1209@osaka-med.ac.jp. 3 Department of Internal Medicine (I), Osaka Medical College, 2-7 Daigaku-machi, Takatsuki 569-8686, Japan. in1297@osaka-med.ac.jp. 4 Department of Internal Medicine (I), Osaka Medical College, 2-7 Daigaku-machi, Takatsuki 569-8686, Japan. in1337@osaka-med.ac.jp. 5 Department of Internal Medicine (I), Osaka Medical College, 2-7 Daigaku-machi, Takatsuki 569-8686, Japan. in1120@osaka-med.ac.jp. 6 Department of Internal Medicine (I), Osaka Medical College, 2-7 Daigaku-machi, Takatsuki 569-8686, Japan. terasaki@osaka-med.ac.jp. 7 National Agriculture and Food Research Organization, Agri-Food Business Innovation Center, 3-1-1 Kannondai, Tsukuba 305-8517, Japan. marimy@affrc.go.jp. 8 Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan. tatibana@agr.kyushu-u.ac.jp. 9 Sakai City Medical Center, 1-1-1 Ebaraji-cho, Nishi-ku, Sakai 593-8304, Japan. hanafusa@sakai-hospital.jp. 10 Department of Internal Medicine (I), Osaka Medical College, 2-7 Daigaku-machi, Takatsuki 569-8686, Japan. imagawa@osaka-med.ac.jp. Abstract (1) Background: Arteriosclerosis is associated with high levels of low-density lipoprotein (LDL) cholesterol. O-methylated catechins in "Benifuuki" green tea are expected to reduce cholesterol levels, although there is limited research regarding this topic; (2) Methods: This trial evaluated 159 healthy volunteers who were randomized to receive ice cream containing a high-dose of "Benifuuki" extract including 676 mg of catechins (group H), a low-dose of "Benifuuki" extract including 322 mg of catechins (group L), or no "Benifuuki" extract (group C). Each group consumed ice cream (with or without extract) daily for 12 weeks, and their lipid-related parameters were compared; (3) Results: A significant reduction in the level of lectin-like oxidized LDL receptor-1 ligand containing ApoB (LAB) was detected in group H, compared to groups L and C. No significant differences between the three groups were detected in their levels of total cholesterol, triglycerides, and LDL cholesterol; (4) Conclusions: "Benifuuki" extract containing O-methylated catechins may help prevent arteriosclerosis. KEYWORDS: Benifuuki; LOX-1 ligand; Lectin-like oxidized LDL receptor-1; O-methylated catechin; dyslipidemia PMID: 30029523 PMCID: PMC6073342 DOI: 10.3390/nu10070924 [Indexed for MEDLINE] Free PMC Article