Assessment of Human Health Risk of Toxic Elements Due to Cinnamon Ingestion in the Diet.

Biol Trace Elem Res. 2018 Sep 6. doi: 10.1007/s12011-018-1473-0. [Epub ahead of print] L Gonçalves L1,2, Fernandes T3,4, Bernardo MA3,4, A Brito J3,4. Author information 1 Centro de Investigação Interdisciplinar Egas Moniz (CiiEM), Instituto Universitário Egas Moniz, Campus Universitário - Quinta da Granja, 2829-511, Caparica, Portugal. lgoncalves@egasmoniz.edu.pt. 2 Instituto Universitário Egas Moniz (IUEM), Campus Universitário - Quinta da Granja, 2829-511, Monte de Caparica, Portugal. lgoncalves@egasmoniz.edu.pt. 3 Centro de Investigação Interdisciplinar Egas Moniz (CiiEM), Instituto Universitário Egas Moniz, Campus Universitário - Quinta da Granja, 2829-511, Caparica, Portugal. 4 Instituto Universitário Egas Moniz (IUEM), Campus Universitário - Quinta da Granja, 2829-511, Monte de Caparica, Portugal. Abstract Recent studies highlighted the beneficial action of cinnamon on postprandial glycemia and LDL-cholesterol concentrations, both in healthy subjects and type 2 diabetic patients. Inclusion of 3 to 6 g of cinnamon in diet revealed a beneficial effect on glucose metabolism control in non-diabetic adults during postprandial period. Given the levels of toxic elements present in cinnamon species from different countries, such large daily intakes of cinnamon can easily exceed their maximum permissible limits and, consequently, induce adverse health effects. This study aimed to investigate the elemental concentration profile in cinnamon powder products available in the Portuguese market and to assess the cumulative non-carcinogenic risk to human health due to the exposure to mixtures of such elements through the inclusion of 6 g of cinnamon in diet. Concentrations of Cu, Zn, Fe, Al, Cl, Mn, and Sr were determined by wavelength dispersive X-ray fluorescence spectroscopy in different lots of eight branded and one bulk cinnamon powder products. Linear mixed models have revealed significant differences in concentrations of Zn, Fe, Al, and Cl between brands. In particular, bulk cinnamon samples presented the highest contents of Fe (475.0-490.0 mg kg-1) and Al (1139.0-1336.0 mg kg-1). The non-carcinogenic risk was assessed following EPA's guidelines through the hazard quotient (HQ). Estimated HQ values were lower than the USEPA guideline of 1. Additionally, the hazard index (HI), representing the combined non-carcinogenic effects of all toxic elements, revealed no potential human health risk for heavy consumers of cinnamon (HI = 0.660). AbstractGraphical ᅟ. KEYWORDS: Cinnamon; Elemental analysis; Hazard index; Risk assessment; Toxic metals; WDXRF PMID: 30191399 DOI: 10.1007/s12011-018-1473-0