Volume 236, Issue 3, 5 August 2015, Pages 154–167
Mini review
- Denisa Marginăa,
- Mihaela Iliea, , ,
- Daniela Grădinarua,
- Vasilis P. Androutsopoulosb,
- Demetrios Kouretasc,
- Aristidis M. Tsatsakisb
Highlights
- •
- Food supplements may change the pharmacokinetic profile of drugs.
- •
- Food supplements may change the efficacy of drugs.
- •
- Food and food supplements might induce toxic outcomes in combination with drugs.
Abstract
A
trend in the general population has been observed in recent years
regarding the orientation toward preventive measures in health; in this
context the increased interest from the users and researchers concerning
the active effect of food supplements on the health state and on
longevity, is noticeable. All over the world, the consumption of natural
foods and of vegetal supplements has increased spectacularly over the
last 5–10 years. The decreased prevalence of cardio-vascular diseases
associated with Mediterranean diet, as well as the French paradox
convinced researchers to scientifically document the beneficial outcomes
pointed out by traditional use of plants, and to try to develop
supplements that would have the same positive effects as these noticed
for diet components.
The intense research dedicated
to this topic revealed the fact that food supplements are linked to some
problematic aspects, such as toxicological side effects when associated
with classical synthetic drugs. The food supplement–drug interactions
are submitted to complex issues regarding pharmacokinetic interactions
leading to changes in absorption, distribution, metabolism and excretion
processes with direct impact on effect and toxicological potential.
The
present review based on recent literature aims at discussing the
food–drug interactions with direct impact on efficacy and toxicity of
drugs.
Abbreviations
- ADME, absorption, distribution, metabolism and excretion;
- ROS, reactive oxygen species;
- MDA, malondialdehyde;
- OATP, organic anion transporting polypeptide;
- QQ, quercetin–quinone;
- GSH, glutathione;
- RLE, rat lung epithelial cells;
- LDH, lactate dehydrogenase;
- ABC, ATP binding cassette;
- P-gp, P-glycoprotein;
- MRP 2, multidrug resistance- associated protein 2;
- TMD, transmembrane domain;
- NBD, nucleotide-binding domain;
- BCRP, breast cancer resistance protein;
- SGLT1, Na+- dependent Na1/glucose co-transporter 1;
- HCC, hepatocellular carcinoma cells;
- UGT, UDP-glucuronyltransferase;
- SULT, sulfotransferase
Keywords
- Food supplements;
- Diet components;
- Food–drug interactions;
- Toxic outcomes
Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.
