Molecules. 2015 Oct 21;20(10):19172-88. doi: 10.3390/molecules201019172.
Iridoids and Flavonoids of Four Siberian Gentians: Chemical Profile and Gastric Stimulatory Effect.
Abstract
Some
Gentiana species have been used by the nomadic people of Siberia as
bitter teas or appetizers to eliminate digestive disorders (dyspepsia,
heartburn, nausea, etc.). We studied the most frequently used gentians:
Gentiana algida, G. decumbens, G. macrophylla and G. triflora. The aim
of the present study was to evaluate the phytochemical features and
gastrostimulatnt activity of these four gentian herbs. Five iridoids, seven flavones and mangiferin were detected in gentian herbs
after analysis by microcolumn-RP-HPLC-UV-ESI-MS. A componential
phytochemical profile of the G. decumbens herb is presented for the
first time, as well as information about distinct phytochemicals found
in gentian herbs. HPLC quantification of the specific compounds of gentian herbs
demonstrated the high content of iridoids (24.73-73.53 mg/g) and
flavonoids (12.92-78.14 mg/g). The results of biological activity
evaluation of four gentian decoctions demonstrated their good ability to
stimulate acid-, enzyme- and mucin-forming functions of the stomach
attributed to mostly by iridoids and flavonoids. In general, it can be
claimed that the gentian decoctions can be used as effective and safe
appetizers and are also a good source of biologically active agents.