Curcumin and Boswellia serrata Modulate the Glyco-Oxidative Status and Lipo-Oxidation in Master Athletes

Nutrients. 2016 Nov 21;8(11). pii: E745.

Chilelli NC¹, Ragazzi E², Valentini R³, Cosma C⁴, Ferraresso S⁵, Lapolla A⁶, Sartore G⁷.

Author information

1

Department of Medicine-DIMED, University of Padova, Diabetology and Dietetics, ULSS 16, via dei Colli, 4, 35100 Padova, Italy. ninocristiano.chilelli@phd.unipd.it.

2

Department of Pharmaceutical and Pharmacological Sciences, University of Padova, 35100 Padova, Italy. eugenio.ragazzi@unipd.it.

3

Department of Medicine-DIMED, University of Padova, Diabetology and Dietetics, ULSS 16, via dei Colli, 4, 35100 Padova, Italy. romina.valentini@unipd.it.

4

Department of Laboratory Medicine, University of Padova, 35100 Padova, Italy. chiara.cosma@sanita.padova.it.

5

Department of Medicine-DIMED, University of Padova, Diabetology and Dietetics, ULSS 16, via dei Colli, 4, 35100 Padova, Italy. stefania.ferraresso@alice.it.

6

Department of Medicine-DIMED, University of Padova, Diabetology and Dietetics, ULSS 16, via dei Colli, 4, 35100 Padova, Italy. annunziata.lapolla@unipd.it.

7

Department of Medicine-DIMED, University of Padova, Diabetology and Dietetics, ULSS 16, via dei Colli, 4, 35100 Padova, Italy. g.sartore@unipd.it.

Abstract

BACKGROUND:

Chronic intensive exercise is associated with a greater induction of oxidative stress and with an excess of endogenous advanced glycation end-products (AGEs). Curcumin can reduce the accumulation of AGEs in vitro and in animal models. We examined whether supplementation with curcumin and Boswellia serrata (BSE) gum resin for 3 months could affect plasma levels of markers of oxidative stress, inflammation, and glycation in healthy master cyclists.

METHODS:

Forty-seven healthy male athletes were randomly assigned to Group 1, consisting of 22 subjects given a Mediterranean diet (MD) alone (MD group), and Group 2 consisted of 25 subjects given a MD plus curcumin and BSE (curcumin/BSE group). Interleukin-6 (IL-6), tumor necrosis factor-α (TNFα), high-sensitivity c-reactive protein (hs-CRP), total AGE, soluble receptor for AGE (sRAGE), malondialdehyde (MDA), plasma phospholipid fatty acid (PPFA) composition, and non-esterified fatty acids (NEFA) were tested at baseline and after 12 weeks.

RESULTS:

sRAGE, NEFA, and MDA decreased significantly in both groups, while only the curcumin/BSE group showed a significant decline in total AGE. Only the changes in total AGE and MDA differed significantly between the curcumin/BSE and MD groups.

CONCLUSIONS:

Our data suggest a positive effect of supplementation with curcumin and BSE on glycoxidation and lipid peroxidation in chronically exercising master athletes.

KEYWORDS:

advanced glycation end-products; curcumin; exercise; inflammation; oxidative stress

PMID:

27879642

PMCID:

PMC5133128

DOI:

10.3390/nu8110745

[Indexed for MEDLINE]

Free PMC Article  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133128/