Green tea as a safe alternative approach for nonalcoholic fatty liver treatment: A systematic review and meta-analysis of clinical trials.

Phytother Res. 2018 Oct;32(10):1876-1884. doi: 10.1002/ptr.6130. Epub 2018 Jun 27. Mansour-Ghanaei F1, Hadi A1, Pourmasoumi M1, Joukar F2, Golpour S1, Najafgholizadeh A3. Author information 1 Gastrointestinal and Liver Diseases Research Center (GLDRC), Guilan University of Medical Sciences (GUMS), Rasht, Iran. 2 Caspian Digestive Diseases Research Center, Guilan University of Medical Sciences (GUMS), Rasht, Iran. 3 Department of Microbiology, Naein Branch, Islamic Azad University Isfahan, Naein, Iran. Abstract This study aimed to evaluate the efficacy of green tea supplementation on nonalcoholic fatty liver disease treatment. Electronic databases, including PubMed, Scopus, Web of Science, and Google Scholar, were systematically searched up to October 30, 2017, to identify eligible trials based on the inclusion criteria. The effect size was presented as mean difference with 95% confidence intervals (CI). The meta-analysis of data from four studies indicated significant effects of green tea supplementation in altering alanine aminotransferases (-12.81 U/L; 95% CI: -18.17 to -7.45) and aspartate aminotransferases (-10.91 U/L; 95% CI: -19.66 to -2.17) blood concentrations. Likewise, a favorable effect of green tea administration was observed on body mass index (-2.08 kg/cm2 ; 95% CI: -2.81 to -1.36), triacylglycerol (-31.87 mg/dl; 95% CI: -40.62 to -23.12), total cholesterol (-27.57 mg/dl; 95% CI: -36.17 to -18.98), and low-density lipoprotein cholesterol (-14.15 mg/dl; 95% CI: -23.69 to -4.60), whereas no significant effect was detected on high-density lipoprotein cholesterol concentrations (7.41 mg/dl; 95% CI: -1.49 to 16.30) and homeostasis model assessment of insulin resistance (-4.06; 95% CI: -10.22 to 2.09). This systematic review and meta-analysis of available trials suggests that there are potential benefits of green tea supplementation on nonalcoholic fatty liver disease. KEYWORDS: Camellia sinensis; green tea; meta-analysis; nonalcoholic fatty liver disease; nonalcoholic steatohepatitis; systematic review PMID: 29947156 DOI: 10.1002/ptr.6130