ScientificWorldJournal. 2013 Apr 28;2013:140591. doi: 10.1155/2013/140591. Print 2013.
Roquefort cheese proteins inhibit Chlamydia pneumoniae propagation and LPS-induced leukocyte migration.
Abstract
Inflammation
in atherosclerosis, which could be associated with some subclinical
infections such as C. pneumoniae, is one of the key factors responsible
for the development of clinical complications of this disease. We report
that a proprietary protein extract isolated from Roquefort cheese
inhibits the propagation of C. pneumoniae in a human HL cell line in a
dose-dependent manner, as revealed by the immunofluorescence analysis.
These changes were accompanied by a significant reduction in the
infective progeny formation over the protein extract range of 0.12-0.5
μg/mL. Moreover, short term feeding of mice with Roquefort cheese
(twice, 10 mg per mouse with an interval of 24 hours) led to the
inhibition of the migration of peritoneal leukocytes caused by
intraperitoneal injection of E. coli lipopolysaccharide. These changes
were complemented by a reduction in neutrophil count and a relative
increase in peritoneal macrophages, suggesting that ingestion of Roquefort
could promote regenerative processes at the site of inflammation. The
ability of this protein to inhibit propagation of Chlamydia infection,
as well as the anti-inflammatory and proregenerative effects of Roquefort
itself, may contribute to the low prevalence of cardiovascular
mortality in France where consumption of fungal fermented cheeses is the
highest in the world.
- PMID:
- 23737705
- [PubMed - indexed for MEDLINE]
- PMCID:
- PMC3655667
