Molecules. 2015 Apr 30;20(5):7915-24. doi: 10.3390/molecules20057915.
Cytotoxic Lignan from the Non-Transformed Root Culture of Phyllanthus amarus.
Abstract
A
new lignan from the non-transformed root in vitro cultures of
Phyllanthus amarus was isolated. The structure of the compound was
established on the basis of one- and two-dimensional NMR, as well as
mass spectrometry data, as 7'-oxocubebin dimethylether
(1,4-bis(benzo[d][1,3]dioxol-5-yl)-2,3-bis(methoxymethyl)butan-1-on).
The non-transformed root cultures of P. amarus showed to be a selective
source of this compound. The lignan revealed strong cytotoxic activity
against HeLa cell line with an IC50 value of 3.8 µg/mL.
- PMID:
- 25942372
- [PubMed - in process]
