Volume 100, January 2015, Pages 156-165
a
Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Szeged, Dóm tér 12, Szeged, Hungary
b Rytmion Ltd., Benczúr u. 39, Szeged, Hungary
c Department of Pharmacognosy, University of Szeged, Faculty of Pharmacy, Eötvös u. 6, Szeged, Hungary
b Rytmion Ltd., Benczúr u. 39, Szeged, Hungary
c Department of Pharmacognosy, University of Szeged, Faculty of Pharmacy, Eötvös u. 6, Szeged, Hungary
Abstract
Chelidonium majus
or greater celandine is spread throughout the world, and it is a very
common and frequent component of modern phytotherapy. Although C. majus
contains alkaloids with remarkable physiological effect, moreover,
safety pharmacology properties of this plant are not widely clarified,
medications prepared from this plant are often used internally. In our
study the inhibitory effects of C. majus
herb extracts and alkaloids on hERG potassium current as well as on
cardiac action potential were investigated. Our data show that
hydroalcoholic extracts of greater celandine and its alkaloids,
especially berberine, chelidonine and sanguinarine have a significant
hERG potassium channel blocking effect. These extracts and alkaloids
also prolong the cardiac action potential in dog ventricular muscle.
Therefore these compounds may consequently delay cardiac repolarization,
which may result in the prolongation of the QT interval and increase
the risk of potentially fatal ventricular arrhythmias. © 2014 Elsevier
B.V. All rights reserved.
Author keywords
Arrhythmia; Cardiac action potential; Chelidonium majus; Greater celandine; hERG; QT interval
Indexed keywords
EMTREE drug terms: berberine; chelidonine; Chelidonium extract; coptisine; potassium channel HERG; sanguinarine; alkaloid; plant extract; potassium channel HERG
EMTREE medical terms: action potential duration; adult;
animal experiment; Article; chemical composition; controlled study;
dog; drug effect; drug safety; embryo; female; heart muscle potential;
heart repolarization; heart ventricle wall; human; human cell; male;
nonhuman; potassium current; priority journal; action potential; animal;
antagonists and inhibitors; Chelidonium; chemistry; drug effects; heart; HEK293 cell line; patch clamp technique
Species Index: Canis familiaris; Chelidonium; Chelidonium majus
MeSH: Action Potentials; Alkaloids; Animals; Chelidonium; Dogs; Ether-A-Go-Go Potassium Channels; Female; Heart; HEK293 Cells; Humans; Male; Patch-Clamp Techniques; Plant Extracts
Medline is the source for the MeSH terms of this document.
Medline is the source for the MeSH terms of this document.
Chemicals and CAS Registry Numbers: berberine,
2086-83-1, 633-65-8; chelidonine, 20267-87-2, 476-32-4; coptisine,
3486-66-6, 521-25-5; sanguinarine, 2447-54-3, 5578-73-4;Alkaloids;
Ether-A-Go-Go Potassium Channels; Plant Extracts
ISSN: 0367326X
CODEN: FTRPASource Type: Journal
Original language: English
Publisher: Elsevier
