Core-shell microcapsules of solid lipid nanoparticles and mesoporous silica for enhanced oral delivery of curcumin

Colloids and Surfaces B: Biointerfaces

Volume 140, April 01, 2016, Pages 161-168

Kim, S.^a, 

Diab, R.^a , 

Joubert, O.^b, 

Canilho, N.^a, 

Pasc, A.^a 

 

^a  SRSMC, UMR 7565, Université de Lorraine-CNRS, Vandœuvre-lès-Nancy, France
^b  CITHEFOR, EA 3452, Université de Lorraine, Nancy, 

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Abstract

Newly designed microcapsules (MC) combining a core of solid lipid nanoparticle (SLN) and a mesoporous silica shell have been developed and explored as oral delivery system of curcumin (CU). CU-loaded MC (MC-CU) are 2 μm sized and have a mesoporous silica shell of 0.3 μm thickness with a wormlike structure as characterized by small angle X-ray scattering (SAXS), nitrogen adsorption/desorption and transmission electron microscopy (TEM) measurements. It was found that SLN acts as reservoir of curcumin while the mesoporous shell insures the protection and the controlled release of the drug. MC-CU displayed a pH-dependent in vitro release profile with marked drug retention at pH 2.8 Neutral red uptake assay together with confocal laser scanning microscopy (CLSM) showed a good cell tolerance to MC-CU at relatively high concentration of inert materials. Besides, the cell-uptake test revealed that fluorescent-MC were well internalized into Caco-2 cells, confirming the possibility to use MC for gut cells targeting. These findings suggest that organic core-silica shell microcapsules are promising drug delivery systems with enhanced bioavailability for poorly soluble drugs. © 2015 Elsevier B.V.

Author keywords

Bioavailability; Caco-2 cells; Core-shell mesoporous silica; Curcumin

Indexed keywords

Engineering controlled terms: Biochemistry; Cells; Cytology; Gas adsorption; High resolution transmission electron microscopy; Mesoporous materials; Nanoparticles; Silica; Transmission electron microscopy; X ray scattering

Bioavailability; Caco-2 cells; Confocal laser scanning microscopy; Core-shell microcapsules; Curcumin; Mesoporous Silica; Poorly soluble drugs; Solid lipid nanoparticle (SLN)

Engineering main heading: Shells (structures)

EMTREE drug terms: curcumin; mesoporous silica nanoparticle; nitrogen; solid lipid nanoparticle

EMTREE medical terms: adsorption; Article; biocompatibility; CACO 2 cell line; concentration (parameters); confocal laser microscopy; controlled study; cytotoxicity assay; desorption; drug delivery system; drug release; human; human cell; in vitro study; microcapsule; pH; physical chemistry; priority journal; transmission electron microscopy; X ray crystallography