REtirement in ACTion (REACT) study
This study will assess the effectiveness of a physical activity intervention in reducing mobility-related disability in older people.
Project overviewPhysical inactivity is one of the strongest predictors of physical disability in older adults. An older person who remains fit and active is more likely to retain physical and cognitive function, prevent disease and disability, and enjoy independence, mental well-being and a higher quality of life.
REACT will assess the effectiveness and cost-effectiveness of a community-based physical activity intervention for reducing the progression of mobility-related functional limitations in older people who are at high risk of transition from independence to mobility-related disability.
The REACT intervention is a 12-month programme of group sessions incorporating cardiovascular, strength, co-ordination and flexibility exercise based in leisure centres/health clubs. Sessions will be twice weekly in the Adoption phase (weeks 1-12) and weekly in the Maintenance phase (week 13-52). The sessions will be designed with social engagement and enjoyment as a priority.
REACT is a full-scale pragmatic multi-centre randomised controlled trial with a 24-month follow up. It is based on the successful US LIFE intervention.
From January 2016 onwards, REACT starts recruiting almost 800 people over the age of 65 to take part in the new programme delivered in local community centres in Bath, Bristol, Birmingham and in Devon ensuring economic and ethnic diversity.
Budget: £1.64 million
Funder: National Institute for Health Research - Public Health Research Programme
Project phasesThe project will run from 1 September 2015 - 29 February 2020.
Phase 1: Establishment of project team
- Research Assistants will be recruited at each site.
- NHS ethics application will be prepared and submitted.
- Study protocol will be refined
- Study launch event
Phase 2: Internal pilot studyAn internal pilot study will be conducted with 12 months follow-up to evaluate and optimise the feasibility of the REACT intervention. The proposed trial methods will be evaluated across a diverse sample, spanning multiple ethnic groups and areas varying in deprivation index.
The study will recruit 60 people per site (total 180). Data from this pilot study will be used as part of the main trial.
Duration: 1 February 2016 - 31 May 2017
Phase 3: Full-scale trial of intervention with data collectionA full-scale pragmatic multi-centre randomised controlled trial with quantitative and qualitative data collection will be conducted. This study will recruit 588 people.
Duration: 1 September 2016 - 31 December 2019
Phase 4: Conclusion and write up of findingsData from the study will be analysed and the findings will be written up.
Duration: 1 September 2019 - 29 February 2020
University of Bath
- Dr Afroditi Stathi (Chief Investigator / Physical Activity and Ageing)
- Dr Janet Withall (Trial Manager / Physical Activity and Health)
- Dr James Bilzon (Physiology)
- Dr Gordon Taylor (Health Statistics)
- Dr Sean Williams (Health Statistics)
- Jolanthe de Koning (Research Assistant)
- Max Western (Research Assistant)
- Rachel Chapman (REACT administrator)
University of Birmingham
University of Bristol
- Emeritus Professor Ken Fox (Physical Activity and Health)
University of Exeter
- Professor Colin Greaves (Health Psychology)
- Professor Colin Green (Health Economics)
- Dr Antonieta Medina-Lara (Health Economics)
- Jessica Bollen (Research Assistant)
University of Oxford
- Professor Heidi Johansen-Berg (Brain imaging- Cognitive Function)
- Dr Claire Sexton (Brain imaging-Cognitive Function)
University of West of England
- Professor Selena Gray (Public Health)
- West Bank Charity
- Age UK Birmingham
- Bath and North East Somerset (BANES)
- Jack M. Guralnik, University of Maryland School of Medicine (consultant)
- W. Jack Rejeski, Wake Forest University (consultant)
- Mark Davis (consultant in physical activity measurement)
EnquiriesIf you would like to find out more about this project then email: firstname.lastname@example.org
The Peninsula Clinical Trials Unit at Plymouth University has agreed to support this study by providing a web-based randomisation service and database development.