Sunday, 24 April 2016

REtirement in ACTion (REACT) study

REtirement in ACTion (REACT) study

This study will assess the effectiveness of a physical activity intervention in reducing mobility-related disability in older people.

Project overview

Physical inactivity is one of the strongest predictors of physical disability in older adults. An older person who remains fit and active is more likely to retain physical and cognitive function, prevent disease and disability, and enjoy independence, mental well-being and a higher quality of life.
REACT will assess the effectiveness and cost-effectiveness of a community-based physical activity intervention for reducing the progression of mobility-related functional limitations in older people who are at high risk of transition from independence to mobility-related disability.
The REACT intervention is a 12-month programme of group sessions incorporating cardiovascular, strength, co-ordination and flexibility exercise based in leisure centres/health clubs. Sessions will be twice weekly in the Adoption phase (weeks 1-12) and weekly in the Maintenance phase (week 13-52). The sessions will be designed with social engagement and enjoyment as a priority.
REACT is a full-scale pragmatic multi-centre randomised controlled trial with a 24-month follow up. It is based on the successful US LIFE intervention.
From January 2016 onwards, REACT starts recruiting almost 800 people over the age of 65 to take part in the new programme delivered in local community centres in Bath, Bristol, Birmingham and in Devon ensuring economic and ethnic diversity.
White NHS logo with the words 'National Institute for Health Research' below it
Budget: £1.64 million
Funder: National Institute for Health Research - Public Health Research Programme

Project phases

The project will run from 1 September 2015 - 29 February 2020.

Phase 1: Establishment of project team

  • Research Assistants will be recruited at each site.
  • NHS ethics application will be prepared and submitted.
  • Study protocol will be refined
  • Study launch event
Duration: 1 September 2015 - 31 January 2016

Phase 2: Internal pilot study

An internal pilot study will be conducted with 12 months follow-up to evaluate and optimise the feasibility of the REACT intervention. The proposed trial methods will be evaluated across a diverse sample, spanning multiple ethnic groups and areas varying in deprivation index.
The study will recruit 60 people per site (total 180). Data from this pilot study will be used as part of the main trial.
Duration: 1 February 2016 - 31 May 2017

Phase 3: Full-scale trial of intervention with data collection

A full-scale pragmatic multi-centre randomised controlled trial with quantitative and qualitative data collection will be conducted. This study will recruit 588 people.
Duration: 1 September 2016 - 31 December 2019

Phase 4: Conclusion and write up of findings

Data from the study will be analysed and the findings will be written up.
Duration: 1 September 2019 - 29 February 2020


University of Bath

University of Birmingham

University of Bristol

University of Exeter

University of Oxford

University of West of England



If you would like to find out more about this project then email:

The Peninsula Clinical Trials Unit at Plymouth University has agreed to support this study by providing a web-based randomisation service and database development.