Volume 72, January 2015, Pages 1069–1075
Highlights
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- Glibenclamide-loaded okra gum-alginate blend beads were prepared by ionic-gelation.
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- These beads showed drug entrapment efficiency of 64.19 ± 2.02 to 91.86 ± 3.24%.
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- These beads exhibited sustained drug release pattern over 8 h of dissolution.
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- The swelling and degradation of these beads were influenced by pH of test mediums.
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- These beads also exhibited good mucoadhesivity with goat intestinal mucosa.
Abstract
The utility of isolated okra (Hibiscus esculentus)
gum (OG) was evaluated as a potential sustained drug release
polymer-blends with sodium alginate in the development of controlled
glibenclamide release ionically-gelled beads for oral use. OG was
isolated from okra fruits and its solubility, pH, viscosity and moisture
content were studied. Glibenclamide-loaded OG-alginate blend beads were
prepared using CaCl2 as cross-linking agent through
ionic-gelation technique. These ionically gelled beads showed drug
entrapment efficiency of 64.19 ± 2.02 to 91.86 ± 3.24%. The bead sizes
were within 1.12 ± 0.11 to 1.28 ± 0.15 mm. These glibenclamide-loaded
OG-alginate blend beads exhibited sustained in vitro drug release over a prolonged period of 8 h. The in vitro
drug release from these OG-alginate beads were followed
controlled-release (zero-order) pattern with super case-II transport
mechanism. The beads were also characterized by SEM and FTIR. The
swelling and degradation of these beads was influenced by the pH of the
test medium. These beads also exhibited good mucoadhesivity with goat
intestinal mucosa.
Keywords
- Sodium alginate;
- Okra gum;
- Glibenclamide
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