Original article
Abstract
Objective
To
investigate the neuroprotective effects of four stilbenes, namely
cajaninstilbene acid (CSA), longistyline A, longistyline C, and
cajanolactone A, isolated from the leaves of Cajanus cajan.
Methods
Neuroprotective
effects of the four stilbenes were evaluated using rat pheochromocytoma
cell line (PC12 cells) damage models induced by corticosterone (Cort)
or glutamate. In order to elaborate whether the neuroprotective effects
of stilbenes are related to anti-oxidant properties, both oxidant and
anti-oxidant parameters were measured.
Results
The
results of MTT assay and LDH release assay demonstrated that the four
stilbenes possessed neuroprotective effects. Moreover, the treatment on
PC12 cells with Cort or glutamate (Glu) could significantly increase the
levels of ROS and MDA with decreasing the activities of SOD and CAT.
However, the four tested stilbenes could significantly alleviate such
situation by dropping out the levels of ROS and MDA, as well as
enhancing the activities of SOD and CAT.
Conclusion
These
results provide a scientific basis for further studies to explore the
potential neuroprotective effects on neurodegenerative diseases.
Key words
- anti-oxidants;
- Cajanus cajan;
- corticosterone;
- glutamate;
- stilbenes
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Citing articles (3)
open in overlay
- Available online: July 15, 2015
- Fund:
International Science and Technology Cooperation of China
(2011DFA32730, 1108); National Science and Technology Major Project
(2012ZX09301002-001)
- Corresponding author: Pan RL Tel: +86-10-5783 3275 Fax: +86-10-5783 3299
Copyright © 2015 Tianjin Press of Chinese Herbal
Medicines. Published by Elsevier (Singapore) Pte Ltd. All rights
reserved.
