Volume 121, 4 October 2016, Pages 47–57
Review article
- Food and Pharmacy College, Zhejiang Ocean University and Zhejiang Provincial Engineering Technology Research Center of Marine Biomedical Products, Zhejiang, Zhoushan, 316022, PR China
- Received 29 January 2016, Revised 8 May 2016, Accepted 10 May 2016, Available online 12 May 2016
Highlights
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- The total flavonoid extracts isolation from natural sources were evaluated the antidepressant-like activity.
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- Synthetic flavonoid compounds and their related analogues were investigated the antidepressant-like effect.
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- The structure–activity relationship and mechanism of action of natural and synthetic flavonoid derivatives are discussed.
Abstract
Flavonoids,
possessing a basic phenylbenzopyrone core, are important components of
the human diet, and are found in many medicinal plants. Flavonoids
include chalcones, flavanones and their derivatives. Synthetic and
natural isolated flavonoids display an enormous number of biological
activities such as antitumor, antiplatelet, anti-malarial,
anti-inflammatory, antidepressant and anticonvulsant properties. This
review article focuses on the antidepressant-like effect,
structure–activity relationship and mechanism of action of total
flavonoid extracts isolation from natural sources, flavonoid compounds
and their related analogues.
Graphical abstract
Keywords
- Flavonoids;
- Chalcones;
- Flavanones;
- Antidepressant-like effect;
- Structure-activity relationship
© 2016 Elsevier Masson SAS. All rights reserved.
