Volume 24, Issue 3, May 2016, Pages 322–328
Current Research in Chemical and Pharmaceutical Sciences
Open Access
Abstract
Objective: In this report, the effects of cynomorium flavonoids on mouse model of perimenopausal depression were investigated. Method:
60 ovariectomized female mice were randomly divided into 6 groups
evenly: high, medium and low doses of cynomorium flavonoids groups
(400 mg kg−1, 200 mg kg−1, 100 mg kg−1), Gengnian’an capsule group (675 mg kg−1), soy isoflavones soft capsule group (250 mg kg−1),
and model group. Give the corresponding drug five days after surgery
once a day, consecutive thirty days. The model group and control group
were given the water of same volume. The model related groups were
applied with different stress for consecutive eighteen days. Kill the
mice and remove the thymus, spleen, uterus and one hand of brain when it
is 2 h after the last administration in mice of each group. Observe the
histological changes of each group under light microscope. Results:
By observing the pathological section, compared with model group, the
pathological changes of the uterus and hypothalamus of mice were
significantly improved. The thymic cortex markedly thickened, volume of
splenic nodule also significantly increased, and the number of
lymphocytes significantly increased (p < 0.01). Simulation results show that the high dose of cynomorium flavonoids group has the best effective. Conclusion:
Cynomorium flavonoids on mouse uterus, hypothalamus, thymus and spleen
lesions have a significant role in the improvement. Cynomorium
flavonoids have a good therapeutic effect on mice with perimenopausal
depression
Keywords
- Cynomorium flavonoids;
- Thymus;
- Spleen;
- Uterus;
- Tissue morphology
1. Introduction
Perimenopausal
depression is a mood disorder that occurs during the perimenopause
period. They become prone to mood depression, unresponsiveness, slow
thinking, irritability, and pessimism (Ma, 2013).
Nowadays, the incidence of perimenopausal depression is on the rise.
Over the years, to investigate the effect of cynomorium flavonoids on a
mouse model of perimenopausal depression is more and more important. In
this report, the effects of cynomorium flavonoids on mouse model of
perimenopausal depression were investigated (Tan, 2014).
Cynomorium
flavonoids are extracted from cynomorium, which is a succulent
perennial herb of a parasitic plant in the Cynomorium genus, Cynomorium
family. They have multiple functions, such as scavenging free radicals,
anti-oxidation, anti-aging and anti-stress, regulating immune and
endocrine systems, and improving sexual function (Tian and Miao, 2014). In this report, the effects of cynomorium flavonoids on mouse model of perimenopausal depression were investigated.
