Food Funct. 2016 Dec 8. [Epub ahead of print]
Marhuenda J1, Medina S2, Martínez-Hernández P3, Arina S4, Zafrilla P5, Mulero J5, Oger C6, Galano JM6, Durand T6, Ferreres F2, Gil-Izquierdo A2.
Author information
- 1Research Group on Quality, Safety and Bioactivity of Plant Foods, Department of Food Science and Technology, CEBAS (CSIC), P.O. Box 164, 30100 Campus University Espinardo, Murcia, Spain. smescudero@cebas.csic.es angelgil@cebas.csic.es and Department of Food Technology and Nutrition, Catholic University of San Antonio, Murcia 30107, Spain.
- 2Research Group on Quality, Safety and Bioactivity of Plant Foods, Department of Food Science and Technology, CEBAS (CSIC), P.O. Box 164, 30100 Campus University Espinardo, Murcia, Spain. smescudero@cebas.csic.es angelgil@cebas.csic.es.
- 3Lab of Clinical Analysis, University Hospital Virgen de la Arrixaca, Murcia, Spain and Bodegas Baigorri S.A.U., Ctra. Vitoria-Logroño Km. 53, 01307 Samaniego, Álava, Spain.
- 4Bodegas Baigorri S.A.U., Ctra. Vitoria-Logroño Km. 53, 01307 Samaniego, Álava, Spain.
- 5Department of Food Technology and Nutrition, Catholic University of San Antonio, Murcia 30107, Spain.
- 6Institut des Biomolécules Max Mousseron (IBMM), UMR 5247 - CNRS - University of Montpellier - ENSCM, Faculty of Pharmacy, Montpellier, France.
Abstract
Adrenic acid (AdA) and docosahexaenoic acid (DHA) peroxidation produces F2-dihomo-IsoPs
and neuroprostanes, which have been related to oxidative damage in the
central nervous system. Besides polyphenols, melatonin (MEL) and
hydroxytyrosol (OHTyr) could be partly responsible for the antioxidant
benefits of red wine
(excluding colon derivatives). In order to elucidate whether these
compounds are responsible for the protective antioxidant effects of red wine,
a double-blind, crossover, placebo-controlled in vivo study - involving
the intake of red wines and their native musts by healthy volunteers -
was performed. The urinary metabolites decreased after the
administration of red wines, to a greater extent than after the intake
of their corresponding musts or ethanol. Melatonin is the most effective
compound that protects adrenic acid from oxidative attack, judged by
the reduction in the formation of F2-dihomo-isoprostanes. Similarly, hydroxytyrosol, being the most effective bioactive compound in reducing the formation of F3-neuroprostanes n-6 DPA and F4-neuroprostanes, protected docosahexaenoic and eicosapentaenoic acids from oxidative attack.
