J Nutr. 2016 Dec;146(12):2652S-2654S. Epub 2016 Nov 9.
Cynober L1,2,3,4,
Bier DM5,4,
Kadowaki M6,4,
Morris SM Jr7,4,
Elango R8,4,
Smriga M9.
- 1Clinical Chemistry Laboratory, Cochin Hospital, AP-HP, Paris, France; luc.cynober@aphp.fr.
- 2Biological Nutrition Laboratory and.
- 3EA 4466, Faculty of Pharmacy, Paris Descartes University, Paris, France.
- 4Scientific Advisory Committee of the International Council on Amino Acid Science.
- 5USDA Agricultural Research Service, Children's Nutrition Research Center, Baylor College of Medicine, Houston, TX.
- 6Graduate School of Science and Technology, Niigata University, Niigata, Japan.
- 7University of Pittsburgh School of Medicine, Pittsburgh, PA.
- 8Department
of Pediatrics, School of Population and Public Health, University of
British Columbia, Vancouver, British Columbia, Canada; and.
- 9International Council on Amino Acid Science, Brussels, Belgium.
Abstract
On
the basis of research presented during the 9th Amino Acid Assessment
Workshop, a No Observed Adverse Effect Level (NOAEL) for diet-added
arginine (added mostly in the form of dietary supplements) of 30 g/d and an upper limit of safe intake (ULSI) for diet-added tryptophan (added mostly in the form of dietary supplements) of 4.5 g/d have been proposed. Both recommendations apply to healthy young adults. The total dietary leucine ULSI proposed for elderly individuals is 500 mg · kg-1 · d-1
All 3 recommendations are relevant only to high-quality amino
acid-containing products with specifications corresponding to those
listed in the US Pharmacopeia Because the above amino acids are
extensively utilized as dietary supplements
for various real or perceived benefits, such as vasodilation,
spermatogenesis, sleep, mood regulation, or muscle recovery, the above
safety recommendations will have an important impact on regulatory and
nutritional practices.
© 2016 American Society for Nutrition.
KEYWORDS:
NOAEL; arginine; leucine; safe intake; tryptophan
