Biomed Pharmacother. 2017 Apr 6;90:479-491. doi: 10.1016/j.biopha.2017.03.071. [Epub ahead of print]
- 1
- Independent
Research Team in Cancer Biology and Bioactive Compounds, Mohamed 1st
University, Oujda, Morocco. Electronic address: k.elbairi@ump.ac.ma.
- 2
- Laboratory of Biochemistry and Immunology, Faculty of Sciences, University Mohammed V, Rabat, Morocco.
- 3
- Quality Laboratory of Vegetable and Medicinal Materials, Department of Vegetable Crops and Medicinal Plants, University of Life Sciences in Lublin,Leszczyńskiego Street 58, 20-068 Lublin, Poland.
- 4
- Neuroscience Laboratory, UM6SS-Research Center, Mohammed VI University of Health Sciences, Casablanca, Morocco.
Abstract
A
growing body of evidence supported by numerous studies on tumorigenesis
confirms that it is possible to target various hallmarks of cancer.
Recent studies have shown that plant-derived molecules may be used in
targeting different signaling pathways for cancer drug discovery. The
present paper gives an insight into the anticancer potential of
fenugreek and lists the existing studies that have been carried out to
demonstrate the advantages of the use of fenugreek in cancer treatment
and prevention. It also aims at opening up new perspectives in the
development of new drugs of natural origins in the future clinical
trials. This review article will discuss; (1) the chemical constituents
and bioactive compounds of fenugreek; (2) effects on oxidative stress
and inflammation; (3) effects on proliferation, apoptosis, and invasion;
(4) toxicity of fenugreek; and 5) future directions in cancer drug
development. All of the experimental studies discussed in this paper
suggest that multiple signaling pathways (hallmarks) are involved in the
anticancer activities of fenugreek, but their efficacy is still
unclear, which requires further investigation.
Copyright © 2017 Elsevier Masson SAS. All rights reserved.
KEYWORDS:
Fenugreek; anticancer; cancer hallmarks; drug discovery
