Volume 95, June 2014, Pages 115–120
Isocoumarins from American cockroach (Periplaneta americana) and their cytotoxic activities
Abstract
Four new isocoumarins (1–4), along with three known ones (5–7), were isolated from the 70% ethanol extract of the whole body of the traditional Chinese insect medicine, American cockroach (Periplaneta americana).
The structures with absolute configurations of new compounds were
elucidated by extensive spectroscopic methods in combination with X-ray
diffraction experiment and CD analyses. Compounds 3–5 showed significant cytotoxic activities in HepG2 and MCF-7 cells with IC50 values in the ranges 6.41–23.91 μM and 6.67–39.07 μM, respectively.
Keywords
- American cockroach;
- Periplaneta americana;
- Isocoumarin;
- Cytotoxicity
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