Abstract
This
study was designed to reveal cell growth inhibitory potential of six
different edible mushrooms: Ramaria flava, Agrocybe molesta,
Volvopluteus gloiocephalus, Lactarius deliciosus, Bovista plumbea, and
Tricholoma terreum on HepG2 cells together with their antioxidant and
antibacterial power. Methanolic extracts of V gloiocephalus and aqueous
extracts of R. flava had the most potential cytotoxic effects over HepG2
cells. The best results for 2,2-diphenyl-1-picrylhydrazyl radical
scavenging activities were obtained from both aqueous and methanolic
extracts of R. flava. Methanolic extracts of T. terreum (IC50 = 1.62
mg/mL) and aqueous extracts of B. plumbea (IC50 = 0.49 mg/mL) showed
maximum metal chelating activity. The highest reducing capacities were
observed among the methanolic extracts of R. flava (EC50 = 1.65 mg/mL)
and aqueous extracts of B. plumbea (EC50 = 1.71 mg/ mL).
High-performance liquid chromatography analysis revealed the presence of
many phenolic compounds in macrofungi; gallic acid and p-coumaric acid
were the two main phenolics identified in all extracts. Antibacterial
studies indicated that all six tested mushrooms showed antibacterial
activity on at least three microorganisms. These results indicate that
different extracts of the investigated mushrooms have considerable
cytotoxic, antioxidant, and antibacterial properties and may be utilized
as a promising source of therapeutics.
