Clinical Aspects of Aconitum Preparations (Review)

Planta Medica

Volume 81, Issue 12-13, 10 July 2015, Pages 1017-1028

Tai, C.-J.^ac, 

El-Shazly, M.^ab, 

Wu, T.-Y.^d, 

Lee, K.-T.^ef, 

Csupor, D.^g, 

Hohmann, J.^g, 

Chang, F.-R.^ahij , 

Wu, Y.-C.^adkl 

 

^a  Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, 100, Shih-Chuan 1st Rd., Kaohsiung, Taiwan
^b  Department of Pharmacognosy and Natural Products Chemistry, Faculty of Pharmacy, Ain Shams University, Abassia, Cairo, Egypt
^c  Department of Family Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan

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Abstract

Aconite species have played an important role in human history. Aconitum species have been used worldwide as poisons as well as remedies. Their potential in targeting several ailments such as pain, rheumatism, and lethargy has been recognized by Western, Chinese, and Indian health care practitioners. Aconite use in herbal preparations has declined, especially in Europe and the United States, in the first half of the twentieth century due to several reported toxicity cases. The situation has changed with the application of new technologies for the accurate analysis of its toxic components and the development of efficient detoxification protocols. Some Asian countries started small clinical trials to evaluate the potency and safety of different marketed aconite preparations. The current review summarizes therapeutic uses of aconite preparations in China, Taiwan, India, and Japan. It also highlights clinical trial results with special emphasis on their limitations. Modern drugs and pharmacopoeial preparations derived from aconite are also discussed. © Georg Thieme Verlag KG Stuttgart, New York.

Author keywords

Aconitum; Ayurvedic medicine; fuzi; monkshood; Ranunculaceae; traditional Chinese medicine

Indexed keywords

EMTREE drug terms: alkaloid derivative; antiarrhythmic agent; herbaceous agent; kampo; lappaconitine

EMTREE medical terms: aconite; Ayurveda; Chinese medicine; clinical trial (topic); drug detoxification; drug formulation; heart arrhythmia; heart failure; homeopathy; human; meta analysis (topic); nonhuman; postherpetic neuralgia; randomized controlled trial (topic); Review; Shenfu injection; systematic review (topic); traditional medicine

Species Index: Aconitum; Ranunculaceae

Chemicals and CAS Registry Numbers: lappaconitine, 32854-75-4

ISSN: 00320943 CODEN: PLMEASource Type: Journal Original language: English

DOI: 10.1055/s-0035-1546183Document Type: Review

Publisher: Georg Thieme Verlag

References (122)

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  Chang, F.-R.; Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, 100, Shih-Chuan 1st Rd., Taiwan
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