[INFLUENCE OF MEDICINAL PLANT EXTRACTS ON THE FUNCTIONS AND ANTIOXIDANT PROTECTION OF ERYTHROCYTES IN RATS WITH EXPERIMENTAL DIABETES MELLITUS].
[Article in Russian]
Abstract
Experiments
on rats with diabetes mellitus model induced by streptosotocin and high
(30%) fat diet showed that the daily treatment with aqueous extracts of
great nettle leaves (100 mg/kg) and common burdock roots (25 mg/kg) for
a period of 10 days led to a decrease in the glycemic index and
triglyceride level and produced protective action on erythrocytes both
in animals kept on a fat-rich diet and on the background of a
low-caloric ration. Both medicinal plant extracts were comparable with
reference drug metformin in reducing the concentration of glycosylated
hemoglobin (by 12-31%) and ectoglobular hemoglobin (1.7-1.8 times, p
<0.05), decreasing the content of malonic dialdehyde in erythrocytes
(1.3 times, p < 0.05), and increasing erythrocyte deformability
(1.3-1.4 times, p < 0.05) and activity of their antioxidant enzymes
glutathione peroxidase, glutathione reductase,
glutathione-S-transferase, catalase, and supe- roxide dismutase (1.2-2.6
times, p < 0.05). A diet with usual (8%) fat content improved the
metabolic indices to a lower degree (on the average by 13-21%, p <
0.05) than did the proposed phytotherapy.
