Biofactors. 2016 Aug 18. doi: 10.1002/biof.1309. [Epub ahead of print]
1Department of Medicine, Albert Einstein College of Medicine, Bronx, NY.
Abstract
The recent emergence of a worldwide epidemic of metabolic disorders, such as obesity and diabetes,
demands effective strategy to develop nutraceuticals or pharmaceuticals
to halt this trend. Natural products have long been and continue to be
an attractive source of nutritional and pharmacological therapeutics.
One such natural product is mangiferin (MGF), the predominant
constituent of extracts of the mango plant Mangifera
indica L. Reports on biological and pharmacological effects of MGF
increased exponentially in recent years. MGF has documented antioxidant
and anti-inflammatory effects. Recent studies indicate that it modulates
multiple biological processes involved in metabolism of carbohydrates
and lipids. MGF has been shown to improve metabolic abnormalities and
disorders in animal models and humans. This review focuses on the
recently reported biological and pharmacological effects of MGF on
metabolism and metabolic disorders. © 2016 BioFactors, 2016.
© 2016 International Union of Biochemistry and Molecular Biology.
KEYWORDS:
Mangiferin; hyperglycemia; hyperlipidemia; inflammation; metabolism
