Fitoterapia. 2016 Sep 19. pii: S0367-326X(16)30378-1. doi: 10.1016/j.fitote.2016.09.004. [Epub ahead of print]
- 1Division
of Pharmacognosy and Chemistry of Natural Products, Department of
Pharmacy, University of Athens, 15471, Athens, Greece.
- 2Department of Medical Laboratories Technology, Technological and Educational Institute of Athens, 12243, Athens, Greece.
- 3Faculty
of Pharmaceutical and Biological Science, LUNAM University, University
of Nantes, IICIMED/ERATU-EA 1155, 1 Rue Gaston Veil, BP, 53508, Nantes
Cedex 01, France.
- 4Center for Pharmacognostic
Research on Panamanian Flora (CIFLOPAN), University of Panama, 10767,
Panama City, Republic of Panama.
- 5Division of
Pharmacognosy and Chemistry of Natural Products, Department of Pharmacy,
University of Athens, 15471, Athens, Greece. Electronic address:
ichinou@pharm.uoa.gr.
Abstract
Two
new natural products,
5-O-[β-D-apiofuranosyl-(1→6)-β-D-glucopyranosyl]-1-isoindolinone (1) as
well as
N-(2E)-3-[(2S,3R)-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-7-methoxy-2,3-dihydro-1-benzofuran-5-yl]acryloylglycine
(2), along with four known compounds (3-6), were isolated from the
methanolic extract of Cordia alliodora root bark. Furthermore, the methanolic extract of Cordia
colloccoca leaves, afforded the known flavonoids afzelin (7) and
quercitrin (8). The isolated secondary metabolites were assayed for
their antimicrobial activities against a panel of six Gram positive and
negative bacteria and three human pathogenic fungi. Moreover, their
antiproliferative effect was also evaluated in vitro against the human
non-small-cell bronchopulmonary carcinoma line NSCLC-N6, the epidermoid
lung cancer cell line A549 as well as the normal human skin fibroblast
cell line (AG01523).
Copyright © 2016. Published by Elsevier B.V.
KEYWORDS:
Boraginaceae; Cordia alliodora; Cordia colloccoca; flavonoid; isoindoline alkaloid; lignanamide
