Fitoterapia. 2015 Apr;102:56-60. doi: 10.1016/j.fitote.2015.02.007. Epub 2015 Feb 21.
- 1Indena S.p.A., Via Don Minzoni 6, 20090 Settala, Italy.
- 2Indena S.p.A., Via Don Minzoni 6, 20090 Settala, Italy. Electronic address: roberto.pace@indena.com.
Abstract
Preparations containing Saw palmetto
extracts are used in traditional medicine to treat benign prostatic
hyperplasia. According to the European and the American Pharmacopoeias,
the extract is obtained from comminuted Saw palmetto
berries by a suitable extracting procedure using ethanol or
supercritical carbon dioxide or a mixture of n-hexane and
methylpentanes. In the present study an approach to metabolomics profiling
using nuclear magnetic resonance (NMR) has been used as a
finger-printing tool to assess the overall composition of the extracts.
The phytochemical analysis coupled with principal component analysis
(PCA) showed the same composition of the Saw palmetto
extracts obtained with carbon dioxide and hexane with minor not
significant differences for extracts obtained with ethanol. In fact
these differences are anyhow lower than the batch-to-batch variability
ascribable to the natural-occurring variability in the Saw palmetto
fruits' phytochemical composition. The fingerprinting analysis combined
with chemometric method, is a technique, which would provide a tool to
comprehensively assess the quality control of Saw palmetto extracts.
Copyright © 2015 Elsevier B.V. All rights reserved.
KEYWORDS:
(1)H nuclear magnetic spectroscopy; Acylglycerols; Metabolomics; Sabal serrulata (Michx.) Nutt. and Schult; Saw palmetto; Serenoa repens (Bartr.) Small
