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Thursday, 12 March 2015

What do we know about phytotherapy of benign prostatic hyperplasia?

Review article

What do we know about phytotherapy of benign prostatic hyperplasia?




doi:10.1016/j.lfs.2015.01.023
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Abstract

Benign prostatic hyperplasia (BPH) is one of the most common urological diseases in aging men. Because of its long latency, BPH is a good target for prevention. The aim of the study has been to review the various options of treatment, currently available, in the field of phytotherapy. Watchful waiting, pharmacological therapy, and surgery are also helpful, depending on the severity of the disease. Although drug therapy (alpha1-blockers, 5alpha-reductase inhibitors) and surgery (prostatectomy, transurethral resection, etc.) seem to be most effective for patients with moderate-severe BPH, herbal medicines (i.e., Serenoa repens, Pygeum africanum, Urtica dioica) are also commonly used in patients with mild–moderate symptoms. On the basis of preclinical studies several mechanisms of action have been postulated, including 5alpha-reductase inhibition, alpha-adrenergic antagonism, dihydrotestosterone and estrogen receptor inhibition. Randomized clinical trials indicate significant efficacy in improving urinary symptoms and mild adverse effects for some phytotherapeutic agents, while further clinical evidence is needed for others (e.g., Epilobium spp., Secale cereale, Roystonea regia). Healthcare professionals should be constantly informed about BPH phytotherapy, taking into account the risk/benefit profile of the use of medicinal plants in the management of BPH.

Chemical compounds studied in this article

  • β-Sitosterol (PubChem CID: 222284);
  • Palmitic acid (PubChem CID: 985);
  • Tamsulosin (PubChem CID: 129211);
  • Finasteride (PubChem CID: 57363);
  • Stigmasterol (PubChem CID: 5280794);
  • Kaempferol (PubChem CID: 5280863);
  • Lycopene (PubChem CID: 446925);
  • Rooperol (PubChem CID: 6438989);
  • n-Docosanol (PubChem CID: 12620);
  • Selenium (PubChem CID: 6326970)

Keywords

  • Benign prostatic hyperplasia;
  • Phytotherapy;
  • Saw palmetto;
  • Clinical efficacy;
  • Safety profile;
  • Review

Corresponding author at: Department of Physiology and Pharmacology “V. Erspamer”, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy. Tel.: + 39 06 49912904; fax: + 39 06 49912480.
Copyright © 2015 Elsevier Inc. All rights reserved.
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