Fitoterapia

Volume 95, June 2014, Pages 34–41

Anti-HIV-1 tigliane diterpenoids from Excoecaria acertiflia Didr

• Sheng-Zhuo Huang^a, b, 
• Xuan Zhang^c, 
• Qing-Yun Ma^a, 
• Hua Peng^b, 
• Yong-Tang Zheng^c, 
• Jiang-Miao Hu^b,
• Hao-Fu Dai^a, 
• Jun Zhou^b, , , 
• You-Xing Zhao^a, , 

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doi:10.1016/j.fitote.2014.02.018

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Abstract

Three tigliane-type diterpenoids named excoecafolins A–C and two daphnane-type diterpenoids named excoecafolins D and E, together with 13 known compounds, were isolated from the EtOAc extract ofExcoecaria acerifolia Didr. Their structures were elucidated through the analysis of the spectroscopic data. The anti-HIV-1 activity evaluation of five of these compounds showed that four possessed moderate anti-HIV-1 activities with EC₅₀ 0.258, 0.036, 0.046, and 0.978 μM, SI > 1,836.9, 431.1, 298.7, and > 503.7, respectively. Additionally, the chemotaxonomic issue of the affinity correlation between Thymelaeceae and Euphorbiaceae is discussed based on the isolates.

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Graphical abstract

Chemical compounds studied in this article

• 4-O-methyl-TPA (PubChem CID 72292); 
• excoecariatoxin (PubChem CID 6442008); 
• schisanwilsonene A (PubChem CID 56671370); 
• caryolanel,9β-diol (PubChem CID 44559977); 
• dapneolon (PubChem CID 5316300); 
• daphneticin (PubChem CID 158341); 
• catechin (PubChem CID 9064)

Keywords

• Excoecaria acerifolia; 
• Euphorbiaceae; 
• Excoecafolin; 
• Anti-HIV-1; 
• Chemotaxonomy

Corresponding authors. Tel./fax: + 86 898 66989095.

Copyright © 2014 Elsevier B.V. All rights reserved.