Chinese Journal of Natural Medicines

Volume 12, Issue 12, December 2014, Pages 881–894

Anticancer and multidrug-resistance reversing potential of traditional medicinal plants and their bioactive compounds in leukemia cell lines

• Ravichandran Senthilkumar^{a, b},
• Bao-An CHEN^{a, b, ,} ,
• Xiao-Hui CAI^{a, b},
• Rong FU^c

doi:10.1016/S1875-5364(14)60131-X

Get rights and content

---

Abstract

Multidrug resistance remains a serious clinical problem in the successful therapy of malignant diseases. It occurs in cultured tumor cell lines, as well as in human cancers. Therefore, it is critical to develop novel anticancer drugs with multidrug-resistance modulating potential to increase the survival rate of leukemia patients. Plant-derived natural products have been used for the treatment of various diseases for thousands of years. This review summarizes the anticancer and multidrug-resistance reversing properties of the extracts and bioactive compounds from traditional medicinal plants in different leukemia cell lines. Further mechanistic studies will pave the road to establish the anticancer potential of plant-derived natural compounds.

Key Words

• Traditional medicinal plants;
• Leukemia;
• Multidrug resistance (MDR);
• Reversal multidrug resistance;
• Apoptosis

Available online 20 Dec. 2014

[Research funding] This project was supported by the National Natural Science Foundation of P.R. China(Nos. 81170492, 81370673), National High Technology Research and Development Program 863 of P.R. China(No. 2012AA022703), National Key Basic Research Program 973 of P.R. China(No. 2010CB732404), Key Medical Projects of Jiangsu Province(No. BL2014078) and Key Discipline of Jiangsu Province(2011-2015).

These authors have no conflict of interest to declare.

[Corresponding author] CHEN Bao-An: Prof., Tel: 86-25-8327 2006

Copyright © 2014 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.