Dietary SupplementsSafety, Efficacy and Quality
A volume in Woodhead Publishing Series in Food Science, Technology and Nutrition
2015, Pages 47–68
4 – Pharmacokinetic interactions between drugs and dietary supplements: herbal supplements
Abstract
Dietary
supplements may alter drug pharmacokinetics by influencing luminal
conditions in the intestinal tract, the activity and/or expression of
transporters and enzyme, and drug distribution. This chapter reviews the
potential of herbal ingredients in dietary supplements to disrupt drug
pharmacokinetics. A summary of the existing literature on (possible)
pharmacokinetic interactions with drugs is presented for key herbal
ingredients.
Keywords
- Pharmacokinetic interactions;
- Dietary supplements (DSs);
- Herbals;
- enzymes;
- Transporters;
- Inhibition;
- Activation;
- Induction;
- Clinical relevance
Copyright © 2015 Elsevier Ltd. All rights reserved.
