Volume 15, May 2015, Pages 44–51
Preclinical and clinical effects of Coleus forskohlii, Salacia reticulata and Sesamum indicum modifying pancreatic lipase inhibition in vitro and reducing total body fat
Highlights
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- C. forskohlii, S. reticulata and S. indicum showed different inhibitory effect on activity of pancreatic lipase.
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- Three herb extracts treatment resulted in synergistically inhibited pancreatic lipase.
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- Supplemented C. forskohlii decreased appetite.
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- C. forskohlii significantly decreased caloric intake in the clinical study.
Abstract
The herbal composition of Coleus forskohlii, Salacia reticulata, and Sesamum indicum, standardized for forskolin, mangiferin, and sesamin, respectively, were shown, in vitro,
to inhibit pancreatic lipase with differing degrees and dynamics. In
the placebo controlled six weeks clinical study the daily intake of
1000 mg C. forskohlii stand-alone standardized for 10%
forskolin, showed statistically significant lowering of total body fat
vs. baseline and placebo group (p < 0.05). The computerized
tomography showed decrease of total body fat and visceral fat in C. forskohlii
group in comparison to the baseline. The potential of three herbal
extracts preventing dietary fat absorption was emphasized by the in vitro synergy between C. forskohlii and S. reticulata inhibiting pancreatic lipase at higher rate than the fat-blocking activity generated by each component alone. The in vitro addition of S. indicum
to the formula was found to synergistically assist inhibition of the
pancreatic lipase in a lower dose range, while moderating the pancreatic
lipase inhibition in a higher dose range. This dual mechanism of S. indicum
was postulated as a safety mechanism preventing any potential side
effects resulting from excessive inhibition of pancreatic lipase
activity.
Abbreviations
- PLT, pancreatic triacylglycerol lipase;
- CCK, cholecystokinin;
- PYY, Peptide YY or Peptide tyrosine tyrosine;
- GLP-1, glucagon-like peptide 1
Keywords
- Coleus forskohlii;
- Salacia reticulata;
- Sesamum indicum;
- Pancreatic lipase;
- Body fat
- Corresponding
author. Institute of Food Science and Technology, National Taiwan
University, 1 Roosevelt Road Section 4, Taipei 10617, Taiwan. Tel.:
+886 2 33664133; fax: +886 2 33661771.
Copyright © 2015 Elsevier Ltd. Published by Elsevier Ltd. All rights reserved.
