Planta Med 2014; 80(06): 437-451
DOI: 10.1055/s-0034-1368351
Reviews
Georg Thieme Verlag KG Stuttgart · New York
Preclinical Evidence for the Pharmacological Actions of Naringin: A
Review
Saurabh Bharti, Neha Rani, Bhaskar Krishnamurthy, Dharamvir Singh Arya
-
Department of Pharmacology, All India Institute of Medical Sciences, New Delhi,
India
Abstract
Naringin, chemically 4′,5,7- trihydroxyflavanone-7-rhamnoglucoside, is a major flavanone
glycoside obtained from tomatoes, grapefruits, and many other citrus fruits. It has been
experimentally documented to possess numerous biological properties such as antioxidant,
anti-inflammatory, and antiapoptotic activities. In vitro and in vivo studies have
further established the usefulness of naringin in various preclinical models of atherosclerosis,
cardiovascular disorders, diabetes mellitus, neurodegenerative disorders, osteoporosis, and
rheumatological disorders. Apart from this, naringin has also exerted chemopreventive and
anticancer attributes in various models of oral, breast, colon, liver, lung, and ovarian cancer.
This wide spectrum of biological expediency has been documented to be a result of either the
upregulation of various cell survival proteins or the inhibition of inflammatory processes, or a
combination of both. Due to the scarcity of human studies on naringin, this review focuses on
the various established activities of naringin in in vitro and in vivo preclinical
models, and its potential therapeutic applications using the available knowledge in the
literature. Additionally, it also encompasses the pharmacokinetic properties of naringin and its
inhibition of CYP isoenzymes, and the subsequent drug interactions. Moreover, further clinical
research is evidently needed to provide significant insights into the mechanisms underlying the
effects of naringin in humans.
Key words
naringin -
flavonoid -
antioxidant -
anti-inflammatory -
atherosclerosis -
diabetes mellitus -
neurological disorders -
cardiovascular disorders -
hepatoprotection -
nephroprotection -
bone diseases -
gastrointestinal diseases -
metabolic syndrome -
dentistry -
cancer -
allergy -
drug interaction -
pharmacokinetics
