Article first published online: 3 DEC 2015
DOI: 10.1002/ptr.5525
Copyright © 2015 John Wiley & Sons, Ltd.
Issue
Phytotherapy Research
Keywords:
- anti-obesity;
- anti-diabetes;
- pancreatic lipase inhibition;
- α-amylase inhibition;
- medicinal plants
In
order to find new pancreatic lipase (PL) and α-amylase inhibitors from
natural sources for the treatment of obesity and related diseases as
diabetes mellitus II, 23 medicinal plants with weight-reducing, serum
glucose-reducing or related potential were investigated. Methanolic and
water extracts of the plants were evaluated by using two in vitro test systems. Our findings have shown that the methanolic extract of Hibiscus sabdariffa L. (Malvaceae) showed high inhibitory activities to PL (IC50: 35.8 ± 0.8 µg/mL) and α-amylase (IC50: 29.3 ± 0.5 µg/mL). Furthermore, the methanolic extract of Tamarindus indica L. (Leguminosae) showed a high anti-lipase (IC50: 152.0 ± 7.0 µg/mL) and the aqueous extract a high anti-amylase (IC50:
139.4 ± 9.0 µg/mL) activity. This work provides a priority list of
interesting plants for further study with respect to the treatment of
obesity and associated diseases. Copyright © 2015 John Wiley & Sons,
Ltd.