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Friday, 10 June 2016

State of knowledge about drugs used during pregnancy and their toxicity to the fetus - Preliminary report

Volume 26, Issue 2, 2013, Pages 211-214
Open Access


Department of Periodontology, Unit of Oral Pathology, Wroclaw Medical University, 26 Krakowska Str, 50-425 Wrocław, Poland
Department of Gynecology and Obstetrics, Faculty of Health Sciences, Wroclaw Medical University, Poland

Abstract

Most drugs pass through the placenta because of its small weight. What remains inadequate, is patients' awareness of pharmacotherapy during pregnancy. There are not so many experiments showing the knowledge about pharmacotherapy during pregnancy among women. In the present study authors wanted to demonstrate what is the knowledge of women about drugs toxicity in FDA pregnancy categories, the use of prescription drugs and biological products, and what kind of drugs, supplements of diet and herbal products were used by patients during pregnancy. The aim was also to reveal knowledge about drugs toxicity on fetus. Questionnaire survey was anonymous, and done by a midwife 1-3 days after parturition. Patients were women from region of Lower Silesia (Poland), who chose to give birth in the Clinic of Gynecology and Obstetrics, Chalubinskiego Street in Wroclaw. Research resulted in 60 questionnaires received from women. Percentage of patients, who had been taking supplementation with folic acid and vitamins reached 77%. As much as 45% of women who took part in research had used pharmacotherapy during pregnancy. From all women, 17% declared to have taken herbal preparations for common cold, fever, cough. Result of the study revealed that 23% of women who took part in the study knew about the FDA division of drugs used during pregnancy. The knowledge about possible teratogenic effect of the drugs is not yet well established among women after parturition. Special observations have to be done among pregnant women for broadening the knowledge about pharmacotherapy in pregnancy and women's treatment habits during pregnancy. 2013 © Curr. Issues Pharm. Med. Sci.

Author keywords

Drug therapy; Drug toxicity; Herb-drug interactions; Pregnancy pharmacology

Indexed keywords

EMTREE drug terms: alpha tocopherol; amoxicillin; ascorbic acid; biological product; cefuroxime axetil; chlorquinaldol; drotaverine; ferrous fumarate; folic acid; furazidin; herbaceous agent; iodine; iron; levothyroxine; magnesium; manganese; metronidazole; nifuratel; nystatin; prescription drug; progesterone; vitamin; vitamin B complex; vitamin D; zinc
EMTREE medical terms: article; awareness; birth; clinical research; common cold; coughing; diet supplementation; drug safety; female; fetotoxicity; fetus; fever; food and drug administration; gynecologist; health survey; herbal medicine; human; knowledge; major clinical study; midwife; Poland; pregnant woman; prenatal drug exposure; prescription; questionnaire; teratogenicity
Chemicals and CAS Registry Numbers: alpha tocopherol, 1406-18-4, 1406-70-8, 52225-20-4, 58-95-7, 59-02-9; amoxicillin, 26787-78-0, 34642-77-8, 61336-70-7; ascorbic acid, 134-03-2, 15421-15-5, 50-81-7; cefuroxime axetil, 64544-07-6; chlorquinaldol, 72-80-0; drotaverine, 14009-24-6, 861-27-8, 985-12-6; ferrous fumarate, 141-01-5, 7705-12-6; folic acid, 59-30-3, 6484-89-5; furazidin, 1672-88-4; iodine, 7553-56-2; iron, 14093-02-8, 53858-86-9, 7439-89-6; levothyroxine, 51-48-9; magnesium, 7439-95-4; manganese, 16397-91-4, 7439-96-5; metronidazole, 39322-38-8, 443-48-1; nifuratel, 4936-47-4; nystatin, 1400-61-9, 34786-70-4, 62997-67-5; progesterone, 57-83-0; zinc, 14378-32-6, 7440-66-6
ISSN: 2084980XSource Type: Journal Original language: English
DOI: 10.12923/j.2084-980X/26.2/a.20Document Type: Article
  Duś, I.M.; Department of Periodontology, Unit of Oral Pathology, Wroclaw Medical University, 26 Krakowska Str, 50-425 Wrocław, Poland; email:irena.dus@gmail.com
© Copyright 2013 Elsevier B.V., All rights reserved.