Br J Nutr. 2016 Sep;116(6):979-88. doi: 10.1017/S0007114516002920. Epub 2016 Aug 4.
11Centro Andaluz de Biología del Desarrollo (CABD),Centro de
Investigación Biomédica en Red de Enfermedades Raras (CIBERER)-Instituto
de Salud Carlos III,Universidad Pablo de Olavide-CSIC,Carretera de
Utrera Km 1,41013Sevilla,Spain.
Abstract
Decrease
in muscle mass and performance with ageing is one of the main factors
of frailty in the elderly. Maintenance of muscle performance by
involving in physical activities is essential to increase independence
and quality of life among elderly. The use of natural compounds with
ergogenic activity in old people would increase the effect of moderate
exercises in the maintenance of physiological muscle capacity.
Resveratrol (RSV), a polyphenol found in walnuts, berries and grapes,
shows this ergogenic activity. By using young, mature and old mice as
models, we have found that RSV improves muscle performance in mature and
old animals but not in young animals. Without showing significant
effect by itself, RSV primed the effect of exercise by increasing
endurance, coordination and strength in old animals. This effect was
accompanied by a higher protection against oxidative damage and an
increase in mitochondrial mass. RSV increased catalase and superoxide
dismutase protein levels in muscle and primed exercise to reverse the
decrease in their activities during ageing. Furthermore, RSV increased
the level of mitochondrial mass markers such as cytochrome C,
mitochondrial transcription factor A and nuclear respiratory factor-1 in
muscle in exercised animals. Our results indicate that RSV can be
considered an ergogenic compound that helps maintain muscle performance
during ageing and subsequently reduces frailty and increases muscle
performance in old individuals practising moderate exercise.
KEYWORDS:
Ageing;
CAT catalase; CR energy intake restriction; CytB5Rase cytochrome B5
reductase; Exercise; GPx glutathione peroxidise; Metabolism and
metabolic studies; Mitochondria; Muscles; NQO1 NAD(P)H quinone
dehydrogenase 1; Polyphenols; RSV resveratrol; SOD superoxide dismutase
