Isolation of major components from the roots of Godmania aesculifolia and determination
of their antifungal activities.
Abstract
From the methanol root extract of Godmania
aesculifolia, a species selected in a multinational OAS program aimed at
discovering antifungal compounds from Latin American plants, a new
chavicol diglycoside (1), the known
3,4-dihydroxy-2-(3-methylbut-2-en-1-yl)-3,4-dihydronaphthalen-1(2H)-one
(2), and lapachol (3) were isolated and characterized by 1D and 2D NMR
and MS techniques. Only 3 exhibited fairly good activity against a panel
of clinical isolates of Cryptococcus neoformans (MIC50 between 7.8 and
31.2 µg/mL) and moderate activities against Candida spp. and
non-albicans Candida spp.
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