Bioorganic & Medicinal Chemistry Letters

Volume 25, Issue 8, 15 April 2015, Pages 1742–1746

Glycyrrhizic acid derivatives as influenza A/H1N1 virus inhibitors

• Lidia A. Baltina^{a, ,} ,
• Vladimir V. Zarubaev^b,
• Lia A. Baltina^a,
• Iana A. Orshanskaya^b,
• Alina I. Fairushina^a,
• Oleg I. Kiselev^b,
• Marat S. Yunusov^a

doi:10.1016/j.bmcl.2015.02.074

Get rights and content

---

Abstract

This Letter describes the synthesis and antiviral activity study of some glycyrrhizic acid (GL) derivatives against influenza A/H1N1/pdm09 virus in MDCK cells. Conjugation of GL with l-amino acids or their methyl esters, and amino sugar (d-galactose amine) dramatically changed its activity. The most active compounds were GL conjugates with aromatic amino acids methyl esters (phenylalanine and tyrosine) (SI = 61 and 38), and S-benzyl-cysteine (SI = 71). Thus modification of GL is a perspective route in the search of new antivirals, and some of GL derivatives are potent as anti-influenza A/H1N1 agents.

---

Graphical abstract

Keywords

• Glycyrrhizic acid;
• Derivatives;
• Analogs;
• Influenza A/H1N1 virus;
• Antivirals

Corresponding author. Tel./fax: +7 (3472)2356066.

Copyright © 2015 Elsevier Ltd. All rights reserved.