Volume 99, July 2015, Pages 129–131
Research note
COX-1 inhibitory effect of medicinal plants of Ghana
Highlights
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- Seventeen plant species used over centuries in Ghana for inflammatory ailments.
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- Investigation for COX-1 inhibition.
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- Four species showed high inhibition.
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- The four active species did not contain tannins as seen in HPLC profiles.
Abstract
Plants
used to treat inflammatory ailments, pain, fever and infections in
Ghana, were tested for COX-1 inhibitory activity. Ethanolic extracts of
17 species were tested in a COX-1 assay. The extracts of Gardenia ternifolia, Thonningia sanguinea, Triumfetta rhomboidea, and the root of Zanthoxylum zanthoxyloides
showed an inhibitory effect over 90% in the final concentration
0.1 μg/μL. The HPLC profiles indicated that the extracts of the four
active species did not contain tannins. The observed in vitro activities support the use of some of the plant species in the traditional medicine system in Ghana.
Keywords
- Ghana;
- COX;
- HPLC;
- Medicinal plants
- Corresponding author. Tel.:
+ 45 35336339; fax: + 45 35336041.
Copyright © 2015 South African Association of Botanists. Published by Elsevier B.V. All rights reserved.
